Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7S8L

SPECIES

Homo sapiens

RESOLUTION

2.450

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04126-6

PUBLICATION DATE

Nov. 17, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cortistatin 14 N85 2.60x60 TM2 Van der Waals
Cortistatin 14 N85 2.60x60 TM2 polar (hydrogen bond)
Cortistatin 14 Y89 2.64x64 TM2 Van der Waals
Cortistatin 14 Y89 2.64x64 TM2 hydrophobic
Cortistatin 14 P102 ECL1 Van der Waals
Cortistatin 14 P102 ECL1 polar (hydrogen bond with backbone)
Cortistatin 14 F105 3.28x28 TM3 hydrophobic
Cortistatin 14 T106 3.29x29 TM3 Van der Waals
Cortistatin 14 T106 3.29x29 TM3 polar (hydrogen bond)
Cortistatin 14 M109 3.32x32 TM3 Van der Waals
Cortistatin 14 C168 4.64x64 TM4 Van der Waals
Cortistatin 14 D184 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Cortistatin 14 W243 6.55x55 TM6 polar (hydrogen bond with backbone)
Cortistatin 14 W243 6.55x55 TM6 Van der Waals
Cortistatin 14 F244 6.56x56 TM6 Van der Waals
Cortistatin 14 H261 7.35x34 TM7 Van der Waals

Ligands

Cortistatin 14

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM2
2x60 2.60x60 N85
2x64 2.64x64 Y89
TM3
3x28 3.28x28 F105
3x29 3.29x29 T106
3x32 3.32x32 M109
TM4
4x64 4.64x64 C168
TM5
5x40 5.40x40 D184
TM6
6x55 6.55x55 W243
6x56 6.56x56 F244
TM7
7x34 7.35x34 H261