Structure information

FPR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T6T

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28586-0

PUBLICATION DATE

March 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
synthetic peptide F81 2.60x60 TM2 hydrophobic
synthetic peptide F102 3.29x29 TM3 hydrophobic
synthetic peptide V105 3.32x32 TM3 hydrophobic
synthetic peptide D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
synthetic peptide L109 3.36x36 TM3 Van der Waals
synthetic peptide L109 3.36x36 TM3 hydrophobic
synthetic peptide F110 3.37x37 TM3 Van der Waals
synthetic peptide F110 3.37x37 TM3 hydrophobic
synthetic peptide V113 3.40x40 TM3 Van der Waals
synthetic peptide V113 3.40x40 TM3 hydrophobic
synthetic peptide T177 45.51x51 ECL2 Van der Waals
synthetic peptide F178 45.52x52 ECL2 Van der Waals
synthetic peptide F178 45.52x52 ECL2 hydrophobic
synthetic peptide L198 5.35x36 TM5 hydrophobic
synthetic peptide L198 5.35x36 TM5 Van der Waals
synthetic peptide R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
synthetic peptide R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
synthetic peptide G209 5.46x461 TM5 Van der Waals
synthetic peptide W254 6.48x48 TM6 Van der Waals
synthetic peptide Y257 6.51x51 TM6 polar (hydrogen bond)
synthetic peptide Y257 6.51x51 TM6 polar (hydrogen bond)
synthetic peptide Q258 6.52x52 TM6 polar (hydrogen bond)
synthetic peptide A261 6.55x55 TM6 hydrophobic
synthetic peptide A261 6.55x55 TM6 Van der Waals
synthetic peptide A264 6.58x58 TM6 hydrophobic
synthetic peptide A264 6.58x58 TM6 Van der Waals
synthetic peptide T265 6.59x59 TM6 Van der Waals
synthetic peptide I268 ECL3 hydrophobic
synthetic peptide I268 ECL3 Van der Waals
synthetic peptide L272 ECL3 hydrophobic
synthetic peptide L272 ECL3 Van der Waals
synthetic peptide F291 7.43x42 TM7 hydrophobic

Ligands

synthetic peptide

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Residue Diagrams

G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7
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ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR1
TM2
2x60 2.60x60 F81
TM3
3x29 3.29x29 F102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 Y257
6x52 6.52x52 Q258
6x55 6.55x55 A261
6x58 6.58x58 A264
6x59 6.59x59 T265
TM7
7x42 7.43x42 F291