Structure information

FPR2/ALX

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T6U

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28586-0

PUBLICATION DATE

March 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
synthetic peptide L81 2.60x60 TM2 hydrophobic
synthetic peptide D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
synthetic peptide L109 3.36x36 TM3 hydrophobic
synthetic peptide L109 3.36x36 TM3 Van der Waals
synthetic peptide F110 3.37x37 TM3 hydrophobic
synthetic peptide F110 3.37x37 TM3 Van der Waals
synthetic peptide V113 3.40x40 TM3 Van der Waals
synthetic peptide T177 45.51x51 ECL2 Van der Waals
synthetic peptide F178 45.52x52 ECL2 hydrophobic
synthetic peptide F178 45.52x52 ECL2 Van der Waals
synthetic peptide L198 5.35x36 TM5 Van der Waals
synthetic peptide L198 5.35x36 TM5 hydrophobic
synthetic peptide R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
synthetic peptide R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
synthetic peptide W254 6.48x48 TM6 hydrophobic
synthetic peptide W254 6.48x48 TM6 Van der Waals
synthetic peptide F257 6.51x51 TM6 Van der Waals
synthetic peptide A261 6.55x55 TM6 hydrophobic
synthetic peptide A261 6.55x55 TM6 Van der Waals
synthetic peptide G264 6.58x58 TM6 Van der Waals
synthetic peptide V284 7.35x34 TM7 hydrophobic
synthetic peptide V284 7.35x34 TM7 Van der Waals
synthetic peptide F292 7.43x42 TM7 Van der Waals
synthetic peptide F292 7.43x42 TM7 hydrophobic

Ligands

synthetic peptide

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Residue Diagrams

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x55 6.55x55 A261
6x58 6.58x58 G264
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292