Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TRK

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

May 17, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y113 3.33x33 TM3 hydrophobic
iperoxo N117 3.37x37 TM3 Van der Waals
iperoxo N117 3.37x37 TM3 polar (hydrogen bond with backbone)
iperoxo V120 3.40x40 TM3 Van der Waals
iperoxo V120 3.40x40 TM3 hydrophobic
iperoxo W164 4.57x57 TM4 hydrophobic
iperoxo W164 4.57x57 TM4 Van der Waals
iperoxo A203 5.46x461 TM5 Van der Waals
iperoxo A203 5.46x461 TM5 hydrophobic
iperoxo F204 5.47x47 TM5 Van der Waals
iperoxo W413 6.48x48 TM6 hydrophobic
iperoxo W413 6.48x48 TM6 Van der Waals
iperoxo Y416 6.51x51 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 Van der Waals
iperoxo N417 6.52x52 TM6 Van der Waals
iperoxo N417 6.52x52 TM6 polar (hydrogen bond)
iperoxo Y439 7.39x38 TM7 hydrophobic
iperoxo Y439 7.39x38 TM7 Van der Waals
iperoxo C442 7.42x41 TM7 hydrophobic
iperoxo C442 7.42x41 TM7 Van der Waals
iperoxo Y443 7.43x42 TM7 Van der Waals

Ligands

iperoxo

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x33 3.33x33 Y113
3x37 3.37x37 N117
3x40 3.40x40 V120
TM4
4x57 4.57x57 W164
TM5
5x461 5.46x461 A203
5x47 5.47x47 F204
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
6x52 6.52x52 N417
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443