Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYH

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Calcitonin human Y41 N-term aromatic (edge-to-face)
Calcitonin human W79 N-term hydrophobic
Calcitonin human F99 N-term hydrophobic
Calcitonin human P100 N-term Van der Waals
Calcitonin human P100 N-term polar (hydrogen bond with backbone)
Calcitonin human D101 N-term polar (charge-assisted hydrogen bond)
Calcitonin human F102 N-term Van der Waals
Calcitonin human S129 N-term Van der Waals
Calcitonin human Y131 N-term Van der Waals
Calcitonin human Y131 N-term hydrophobic
Calcitonin human T132 N-term Van der Waals
Calcitonin human N135 N-term Van der Waals
Calcitonin human L142 1.33x33 TM1 Van der Waals
Calcitonin human L142 1.33x33 TM1 hydrophobic
Calcitonin human A145 1.36x36 TM1 polar (hydrogen bond with backbone)
Calcitonin human A145 1.36x36 TM1 Van der Waals
Calcitonin human Y146 1.37x37 TM1 polar (hydrogen bond)
Calcitonin human L148 1.39x39 TM1 Van der Waals
Calcitonin human L148 1.39x39 TM1 hydrophobic
Calcitonin human Y149 1.40x40 TM1 Van der Waals
Calcitonin human Y149 1.40x40 TM1 polar (hydrogen bond with backbone)
Calcitonin human I198 2.64x64 TM2 hydrophobic
Calcitonin human I198 2.64x64 TM2 Van der Waals
Calcitonin human H201 2.67x67 TM2 Van der Waals
Calcitonin human V206 ECL1 Van der Waals
Calcitonin human V206 ECL1 polar (hydrogen bond with backbone)
Calcitonin human P207 ECL1 Van der Waals
Calcitonin human P207 ECL1 hydrophobic
Calcitonin human G209 ECL1 Van der Waals
Calcitonin human G209 ECL1 polar (hydrogen bond with backbone)
Calcitonin human V212 ECL1 hydrophobic
Calcitonin human V212 ECL1 Van der Waals
Calcitonin human R213 ECL1 Van der Waals
Calcitonin human Y234 3.44x44 TM3 Van der Waals
Calcitonin human L291 45.52x52 ECL2 Van der Waals
Calcitonin human L291 45.52x52 ECL2 hydrophobic
Calcitonin human S292 ECL2 Van der Waals
Calcitonin human V293 ECL2 Van der Waals
Calcitonin human V293 ECL2 hydrophobic
Calcitonin human Y299 5.37x38 TM5 hydrophobic
Calcitonin human Y299 5.37x38 TM5 Van der Waals
Calcitonin human H302 5.40x40 TM5 Van der Waals
Calcitonin human H302 5.40x40 TM5 polar (hydrogen bond)
Calcitonin human M306 5.44x44 TM5 Van der Waals
Calcitonin human F356 6.53x53 TM6 polar (hydrogen bond with backbone)
Calcitonin human F356 6.53x53 TM6 Van der Waals
Calcitonin human F359 6.56x56 TM6 Van der Waals
Calcitonin human F359 6.56x56 TM6 polar (hydrogen bond with backbone)
Calcitonin human W361 ECL3 hydrophobic
Calcitonin human W361 ECL3 Van der Waals
Calcitonin human R362 ECL3 polar (hydrogen bond with backbone)
Calcitonin human R362 ECL3 Van der Waals
Calcitonin human Y372 7.38x37 TM7 Van der Waals
Calcitonin human H377 7.43x42 TM7 Van der Waals

Ligands

Calcitonin human

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM2
2x57 2.64x64 I198
2x60 2.67x67 H201
TM3
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
6x51 6.56x56 F359
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377