Structure information

H2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UL3

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-022-00859-8

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
famotidine D98 3.32x32 TM3 polar (charge-assisted hydrogen bond)
famotidine V99 3.33x33 TM3 Van der Waals
famotidine T103 3.37x37 TM3 polar (hydrogen bond)
famotidine T103 3.37x37 TM3 Van der Waals
famotidine K175 45.51x51 ECL2 Van der Waals
famotidine V176 45.52x52 ECL2 polar (hydrogen bond with backbone)
famotidine V176 45.52x52 ECL2 Van der Waals
famotidine D186 5.42x43 TM5 polar (charge-assisted hydrogen bond)
famotidine T190 5.46x461 TM5 Van der Waals
famotidine Y250 6.51x51 TM6 polar (hydrogen bond)
famotidine L274 7.39x38 TM7 Van der Waals

Ligands

famotidine

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Residue Diagrams

V N G A V T I L I L V A L V V T I T I K 1 V S L A I T D L L L G L L V L P F S A I Y 2 M F L N L I S A T C L M V D L S T Y I N 3 V A I S L V L I W V I S I T L S F L S I 4 Y T I C M I L L P L Y F T V L G D V L G Y 5 A A V M G A F I I C W F P Y F T A F V Y 6 I P N L A S N A Y G L W L V I A E L V 7
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ICL1 R R L R ICL1ECL1 K W S F ECL1ICL2 P L R Y P V L V ICL2ECL2 W N S R N E T S K G N H T T S K C K V Q V ECL2ICL3 H I S ICL3ECL3 G D D A I ECL3N-term M A P N G T A S S N-termC-term C R L A N R N S H K T S L R S N A S Q L S R T Q S R E P R Q Q E E K P L K L Q V W S G T E V T A P Q G A T D R C-term F C L D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D T P V R V A I S L V L I W V I S I T L S F L S I H L G N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D Y Q Q F R T G L F C
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Residue Table


GPCRdb(A)
GPCRdb(A)
H2 receptor
TM3
3x32 3.32x32 D98
3x33 3.33x33 V99
3x37 3.37x37 T103
ECL2
45x51 45.51x51 K175
45x52 45.52x52 V176
TM5
5x43 5.42x43 D186
5x461 5.46x461 T190
TM6
6x51 6.51x51 Y250
TM7
7x38 7.39x38 L274