Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WC5

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.ABL8615

PUBLICATION DATE

Jan. 26, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
psilocin W151 3.28x28 TM3 aromatic (face-to-edge)
psilocin D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
psilocin V156 3.33x33 TM3 Van der Waals
psilocin L228 45.51x51 ECL2 hydrophobic
psilocin L228 45.51x51 ECL2 Van der Waals
psilocin F339 6.51x51 TM6 hydrophobic
psilocin F339 6.51x51 TM6 Van der Waals
psilocin N343 6.55x55 TM6 Van der Waals
psilocin N363 7.36x35 TM7 Van der Waals

Ligands

psilocin

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
ECL2
45x51 45.51x51 L228
TM6
6x51 6.51x51 F339
6x55 6.55x55 N343
TM7
7x35 7.36x35 N363