Structure information

GAL2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WQ4

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29072-3

PUBLICATION DATE

April 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
galanin Q82 2.61x60 TM2 polar (hydrogen bond)
galanin Q82 2.61x60 TM2 Van der Waals
galanin I85 2.64x63 TM2 Van der Waals
galanin I85 2.64x63 TM2 polar (hydrogen bond with backbone)
galanin Y86 2.65x64 TM2 Van der Waals
galanin L88 2.67x66 TM2 Van der Waals
galanin L88 2.67x66 TM2 polar (hydrogen bond with backbone)
galanin D89 ECL1 Van der Waals
galanin G90 23.49x49 ECL1 polar (hydrogen bond with backbone)
galanin G90 23.49x49 ECL1 Van der Waals
galanin H102 3.29x29 TM3 Van der Waals
galanin Y164 ECL2 hydrophobic
galanin Y164 ECL2 Van der Waals
galanin L169 ECL2 hydrophobic
galanin L169 ECL2 Van der Waals
galanin H176 45.51x51 ECL2 polar (hydrogen bond)
galanin H176 45.51x51 ECL2 polar (hydrogen bond)
galanin P177 45.52x52 ECL2 Van der Waals
galanin P177 45.52x52 ECL2 hydrophobic
galanin R184 5.35x36 TM5 polar (charge-assisted hydrogen bond)
galanin F264 ECL3 Van der Waals
galanin F264 ECL3 hydrophobic
galanin L266 ECL3 hydrophobic
galanin L266 ECL3 Van der Waals
galanin T267 7.28x27 TM7 Van der Waals
galanin T267 7.28x27 TM7 polar (hydrogen bond with backbone)
galanin R268 7.29x28 TM7 Van der Waals
galanin T270 7.31x30 TM7 Van der Waals
galanin Y271 7.32x31 TM7 aromatic (edge-to-face)
galanin Y271 7.32x31 TM7 Van der Waals
galanin R274 7.35x34 TM7 Van der Waals

Ligands

galanin

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Residue Diagrams

T N G V T G V L F I L A F L L P V I V A 1 L N L G V A D L C F I C L C V P F Q A T I 2 A A L T F S S A H M T L F I L F H V A K 3 A L A A I G L I W G L S L L F S G P Y 4 Y T L G L V L V P L L Y S F V F T C I D M 5 L I V A A L F C L C W M P H H A L I L C 6 I P N V C S N A Y S V L H S L I R L A 7
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ICL1 G Q A V ICL1ECL1 D G W V F ECL1ICL2 P L H S R E L R ICL2ECL2 R Q S Q L A N L T V C H P A W ECL2ICL3 A A ICL3ECL3 Q F P L ECL3N-term M N V S G C P G A G N A S Q A G G G G G W H N-termC-term G L L G R A P G R A S G R V C A A A R G T H S G S V L E R E S S D L L H M S E A A G A L R P C P G A S Q P C I L E P C P G P S W Q G P K A G D S I L T V D V A C-term P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V D P V G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R T F R K G I C A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GAL2 receptor
TM2
2x60 2.61x60 Q82
2x63 2.64x63 I85
2x64 2.65x64 Y86
2x66 2.67x66 L88
ECL1
23x49 23.49x49 G90
TM3
3x29 3.29x29 H102
ECL2
45x51 45.51x51 H176
45x52 45.52x52 P177
TM5
5x36 5.35x36 R184
TM7
7x27 7.28x27 T267
7x28 7.29x28 R268
7x30 7.31x30 T270
7x31 7.32x31 Y271
7x34 7.35x34 R274