Structure information

FPR2/ALX

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WVX

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29361-X

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
humanin E89 ECL1 polar (charge-assisted hydrogen bond)
humanin D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
humanin L109 3.36x36 TM3 Van der Waals
humanin L109 3.36x36 TM3 hydrophobic
humanin F110 3.37x37 TM3 hydrophobic
humanin F110 3.37x37 TM3 Van der Waals
humanin V113 3.40x40 TM3 Van der Waals
humanin I169 ECL2 hydrophobic
humanin I169 ECL2 Van der Waals
humanin Y175 ECL2 Van der Waals
humanin Y175 ECL2 aromatic (face-to-edge)
humanin F178 45.52x52 ECL2 Van der Waals
humanin F178 45.52x52 ECL2 hydrophobic
humanin N179 ECL2 polar (hydrogen bond)
humanin N179 ECL2 Van der Waals
humanin F180 ECL2 Van der Waals
humanin F180 ECL2 polar (hydrogen bond with backbone)
humanin A181 ECL2 hydrophobic
humanin A181 ECL2 Van der Waals
humanin R190 5.27x28 TM5 Van der Waals
humanin A194 5.31x32 TM5 Van der Waals
humanin L198 5.35x36 TM5 hydrophobic
humanin L198 5.35x36 TM5 Van der Waals
humanin R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
humanin R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
humanin W254 6.48x48 TM6 Van der Waals
humanin W254 6.48x48 TM6 hydrophobic
humanin F257 6.51x51 TM6 hydrophobic
humanin F257 6.51x51 TM6 Van der Waals
humanin Q258 6.52x52 TM6 polar (hydrogen bond)
humanin L268 ECL3 Van der Waals
humanin L272 ECL3 hydrophobic
humanin L272 ECL3 Van der Waals
humanin V284 7.35x34 TM7 Van der Waals

Ligands

humanin

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Residue Diagrams

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x52 45.52x52 F178
TM5
5x28 5.27x28 R190
5x32 5.31x32 A194
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
TM7
7x34 7.35x34 V284