Structure information

TRH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7X1U

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-022-00646-6

PUBLICATION DATE

Aug. 31, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TRH N82 2.61x60 TM2 polar (hydrogen bond)
TRH T102 3.29x29 TM3 Van der Waals
TRH Q105 3.32x32 TM3 Van der Waals
TRH Y106 3.33x33 TM3 polar (hydrogen bond)
TRH C179 45.50x50 ECL2 Van der Waals
TRH C179 45.50x50 ECL2 polar (hydrogen bond with backbone)
TRH G180 45.51x51 ECL2 polar (hydrogen bond with backbone)
TRH G180 45.51x51 ECL2 Van der Waals
TRH Y181 45.52x52 ECL2 aromatic (face-to-edge)
TRH Y181 45.52x52 ECL2 Van der Waals
TRH R185 ECL2 polar (charge-assisted hydrogen bond)
TRH Y192 5.39x39 TM5 Van der Waals
TRH Y282 6.51x51 TM6 polar (hydrogen bond)
TRH Y282 6.51x51 TM6 polar (hydrogen bond)
TRH Y282 6.51x51 TM6 Van der Waals
TRH N289 6.58x58 TM6 Van der Waals
TRH N289 6.58x58 TM6 polar (hydrogen bond)
TRH L302 7.35x34 TM7 hydrophobic
TRH L302 7.35x34 TM7 Van der Waals
TRH R306 7.39x38 TM7 polar (charge-assisted hydrogen bond)
TRH Y310 7.43x42 TM7 Van der Waals

Ligands

TRH

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Residue Diagrams

I N G V I G L G C I I L V L L I T V V Q 1 V S L A V A D L M V L A V A G L P N I T D 2 A T I S C S S A N I G L Y Q L Y T I C L 3 A K K I I I F V W A F T S L Y C M L W F 4 Y L V T A L I M P V V Y F V G F D M L Y 5 A V V V I L F A L L W M P Y R T L V V V 6 V P N I A S N L Y I C I R C F L L F W 7
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ICL1 K H M R ICL1ECL1 G S W V Y ECL1ICL2 P I K A Q F L C ICL2ECL2 D L N I S T Y K D A I V I S C G Y K ECL2ICL3 N S K T W K N D S T H Q N T N L N V N T S N R C F ICL3ECL3 S S P F Q ECL3N-term M E N E T V S E L N Q T Q L Q P R A V V A N-termC-term C K Q K P T E K P A N Y S V A L N Y S V I K E S D H F S T E L D D I T V T D T Y L S A T K V S F D D T C L A S E V S F S Q S C-term L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H T F S R A K K I I I F V W A F T S L Y C M L W F F L L I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N P I P S D P K E N S T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R K F R A A L C N
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Residue Table


GPCRdb(A)
GPCRdb(A)
TRH1 receptor
TM2
2x60 2.61x60 N82
TM3
3x29 3.29x29 T102
3x32 3.32x32 Q105
3x33 3.33x33 Y106
ECL2
45x50 45.50x50 C179
45x51 45.51x51 G180
45x52 45.52x52 Y181
TM5
5x39 5.39x39 Y192
TM6
6x51 6.51x51 Y282
6x58 6.58x58 N289
TM7
7x34 7.35x34 L302
7x38 7.39x38 R306
7x42 7.43x42 Y310