Structure information

GAL2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XJL

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

F

REFERENCE

10.1073/PNAS.2121465119

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Spexin I85 2.64x63 TM2 polar (hydrogen bond with backbone)
Spexin I85 2.64x63 TM2 Van der Waals
Spexin Y86 2.65x64 TM2 hydrophobic
Spexin Y86 2.65x64 TM2 Van der Waals
Spexin D89 ECL1 Van der Waals
Spexin D89 ECL1 polar (hydrogen bond with backbone)
Spexin G90 23.49x49 ECL1 Van der Waals
Spexin G90 23.49x49 ECL1 polar (hydrogen bond with backbone)
Spexin W91 23.50x50 ECL1 polar (hydrogen bond with backbone)
Spexin W91 23.50x50 ECL1 Van der Waals
Spexin H102 3.29x29 TM3 Van der Waals
Spexin Y164 ECL2 Van der Waals
Spexin Y164 ECL2 polar (hydrogen bond)
Spexin L169 ECL2 Van der Waals
Spexin L169 ECL2 hydrophobic
Spexin V174 ECL2 Van der Waals
Spexin V174 ECL2 hydrophobic
Spexin C175 45.50x50 ECL2 Van der Waals
Spexin H176 45.51x51 ECL2 Van der Waals
Spexin P177 45.52x52 ECL2 hydrophobic
Spexin P177 45.52x52 ECL2 Van der Waals
Spexin R184 5.35x36 TM5 polar (charge-assisted hydrogen bond)
Spexin L266 ECL3 hydrophobic
Spexin L266 ECL3 Van der Waals
Spexin T267 7.28x27 TM7 Van der Waals
Spexin T267 7.28x27 TM7 polar (hydrogen bond with backbone)
Spexin T270 7.31x30 TM7 polar (hydrogen bond)
Spexin Y271 7.32x31 TM7 aromatic (edge-to-face)
Spexin Y271 7.32x31 TM7 Van der Waals
Spexin R274 7.35x34 TM7 Van der Waals

Ligands

Spexin

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Residue Diagrams

T N G V T G V L F I L A F L L P V I V A 1 L N L G V A D L C F I C L C V P F Q A T I 2 A A L T F S S A H M T L F I L F H V A K 3 A L A A I G L I W G L S L L F S G P Y 4 Y T L G L V L V P L L Y S F V F T C I D M 5 L I V A A L F C L C W M P H H A L I L C 6 I P N V C S N A Y S V L H S L I R L A 7
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ICL1 G Q A V ICL1ECL1 D G W V F ECL1ICL2 P L H S R E L R ICL2ECL2 R Q S Q L A N L T V C H P A W ECL2ICL3 A A ICL3ECL3 Q F P L ECL3N-term M N V S G C P G A G N A S Q A G G G G G W H N-termC-term G L L G R A P G R A S G R V C A A A R G T H S G S V L E R E S S D L L H M S E A A G A L R P C P G A S Q P C I L E P C P G P S W Q G P K A G D S I L T V D V A C-term P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V D P V G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R T F R K G I C A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GAL2 receptor
TM2
2x63 2.64x63 I85
2x64 2.65x64 Y86
ECL1
23x49 23.49x49 G90
23x50 23.50x50 W91
TM3
3x29 3.29x29 H102
ECL2
45x50 45.50x50 C175
45x51 45.51x51 H176
45x52 45.52x52 P177
TM5
5x36 5.35x36 R184
TM7
7x27 7.28x27 T267
7x30 7.31x30 T270
7x31 7.32x31 Y271
7x34 7.35x34 R274