Structure information

5-HT4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XT9

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.05.031

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine D99 3.32x32 TM3 polar (hydrogen bond with backbone)
5-hydroxytryptamine D99 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-hydroxytryptamine V100 3.33x33 TM3 polar (hydrogen bond)
5-hydroxytryptamine V100 3.33x33 TM3 polar (hydrogen bond with backbone)
5-hydroxytryptamine T103 3.36x36 TM3 polar (hydrogen bond)
5-hydroxytryptamine T104 3.37x37 TM3 polar (hydrogen bond)
5-hydroxytryptamine T104 3.37x37 TM3 polar (hydrogen bond with backbone)
5-hydroxytryptamine F185 45.52x52 ECL2 polar (hydrogen bond)
5-hydroxytryptamine V187 ECL2 polar (hydrogen bond)
5-hydroxytryptamine Y191 5.38x39 TM5 polar (hydrogen bond)
5-hydroxytryptamine A192 5.39x40 TM5 Van der Waals
5-hydroxytryptamine C195 5.42x43 TM5 Van der Waals
5-hydroxytryptamine C195 5.42x43 TM5 polar (hydrogen bond with backbone)
5-hydroxytryptamine S196 5.43x44 TM5 Van der Waals
5-hydroxytryptamine A199 5.46x461 TM5 Van der Waals
5-hydroxytryptamine W271 6.48x48 TM6 Van der Waals
5-hydroxytryptamine F274 6.51x51 TM6 hydrophobic
5-hydroxytryptamine F274 6.51x51 TM6 Van der Waals
5-hydroxytryptamine F275 6.52x52 TM6 polar (hydrogen bond)
5-hydroxytryptamine F275 6.52x52 TM6 aromatic (edge-to-face)
5-hydroxytryptamine N278 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine N278 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine L297 7.39x38 TM7 polar (hydrogen bond)
5-hydroxytryptamine Y301 7.43x42 TM7 polar (hydrogen bond)

Ligands

5-hydroxytryptamine

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Residue Diagrams

L N G L I A M L I V T S L F T L L V V K 1 V S L A F A D L L V S L V V M P F G A I E 2 C C L H F I S A T T L L V D L S T R V L 3 I A L M L G G C W V I P T F I S F L P I 4 Y A L V M L L F P I Y F A V V S C T I A Y 5 C I I M G C F C L C W A P F F V T N I V 6 F P N L G S N I Y G L W L F A T W V Q 7
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ICL1 R Q L R K ICL1ECL1 I W I Y ECL1ICL2 P Q L V Y R N K M ICL2ECL2 W N N I G I I D L I E K R K F N Q N S N S T Y C V F M V ECL2ICL3 A S S E S R P Q S A D Q H S ICL3ECL3 D Y T V ECL3N-term M D K L D A N V S S E E G F G S N-termC-term D D E R Y R R P S I L G Q T V P C S T T T I N G S T H V L R D A V E C G G Q W E S Q C H P P A T S P L V A A Q P S D T C-term V E K V V L L T F L S T V I L M A I L G N L L V M V A V C W D I K T N Y F I V S L A F A D L L V S V L V M P F G A I E L V Q D G E V F C L V R T S L D V L L T T A S I F H L C C I S L D R Y Y A I C C T P L R I A L M L G G C W V I P T F I S F L P I M Q G N K P Y A I T C S V V A F Y I P F L L M V L A Y Y R I Y V T A K E H A H Q I Q M L Q R A G T H R M R T E T K A A K T L C I I M G C F C L C W A P F F V T N I V D P F I P G Q V W T A F L W L G Y I N S G L N P F L Y A F L N K S F L I F R R A I L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT4 receptor
TM3
3x32 3.32x32 D100
3x33 3.33x33 V101
3x36 3.36x36 T104
3x37 3.37x37 T105
ECL2
45x52 45.52x52 F186
TM5
5x39 5.38x39 Y192
5x40 5.39x40 A193
5x43 5.42x43 C196
5x44 5.43x44 S197
5x461 5.46x461 A200
TM6
6x48 6.48x48 W272
6x51 6.51x51 F275
6x52 6.52x52 F276
6x55 6.55x55 N279
TM7
7x38 7.39x38 L298
7x42 7.43x42 Y302