Structure information

α1A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YMH

SPECIES

Homo sapiens

RESOLUTION

3.520

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-023-39310-X

PUBLICATION DATE

July 5, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Noradrenaline D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Noradrenaline V107 3.33x33 TM3 hydrophobic
Noradrenaline V107 3.33x33 TM3 Van der Waals
Noradrenaline C110 3.36x36 TM3 Van der Waals
Noradrenaline S188 5.42x43 TM5 polar (hydrogen bond)
Noradrenaline F288 6.51x51 TM6 aromatic (edge-to-face)
Noradrenaline F288 6.51x51 TM6 Van der Waals
Noradrenaline F289 6.52x52 TM6 hydrophobic
Noradrenaline F289 6.52x52 TM6 Van der Waals
Noradrenaline F312 7.39x38 TM7 Van der Waals
Noradrenaline Y316 7.43x42 TM7 Van der Waals

Ligands

Noradrenaline

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Residue Diagrams

I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7
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ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
TM5
5x43 5.42x43 S188
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
TM7
7x38 7.39x38 F312
7x42 7.43x42 Y316