Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

8CXO

SPECIES

Mus musculus

RESOLUTION

3.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-022-32125-2

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol W343 3.50x50 TM3 hydrophobic
Cholesterol L423 5.62x62 TM5 hydrophobic
Cholesterol V427 5.66x66 TM5 hydrophobic
Cholesterol F431 5.70x70 TM5 hydrophobic
Cholesterol L454 6.31x31 TM6 hydrophobic
Cholesterol I458 6.35x35 TM6 hydrophobic
Cholesterol F461 6.38x38 TM6 hydrophobic

Ligands

Cholesterol

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R F G E P T S S E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K K P I P D C E I K N R P ECL3N-term M A A G R P V R G P E L A P R R L L Q L L L L V L L G G P G R G A A L S G N V T G P G P H S A S G S S R R D V P V T S P P P P L L S H C G R A A H C E P L R Y N V C L G S A L P Y G A T T T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D H F P E G C P N E V Q N I K F N S S G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G H S D D E P K R I K K S K M I A K A F S K R R E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D V S V T P V A T P V P P E E Q A N M W L V E A E I S P E L E K R L G R K K K R R K R K K E V C P L R P A P E L H H S A P V P A T S A V P R L P Q L P R Q K C L V A A N A W G T G E S C R Q G A W T L V S N P F C P E P S P H Q D P F L P G A S A P R V W A Q G R L Q G L G S I H S R T N L M E A E I L D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM3
3x50 3.50x50 W343
TM5
5x58 5.62x62 L423
5x62 5.66x66 V427
5x66 5.70x70 F431
TM6
6x35 6.31x31 L454
6x39 6.35x35 I458
6x42 6.38x38 F461