Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8E0G

SPECIES

Mus musculus

RESOLUTION

2.100

PREFERRED CHAIN

A

REFERENCE

10.1186/S12915-023-01689-W

PUBLICATION DATE

Oct. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BU72 I144 3.29x29 TM3 hydrophobic
BU72 D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
BU72 Y148 3.33x33 TM3 hydrophobic
BU72 Y148 3.33x33 TM3 Van der Waals
BU72 M151 3.36x36 TM3 hydrophobic
BU72 M151 3.36x36 TM3 Van der Waals
BU72 V236 5.42x43 TM5 Van der Waals
BU72 V236 5.42x43 TM5 hydrophobic
BU72 W293 6.48x48 TM6 hydrophobic
BU72 I296 6.51x51 TM6 hydrophobic
BU72 I296 6.51x51 TM6 Van der Waals
BU72 H297 6.52x52 TM6 Van der Waals
BU72 H297 6.52x52 TM6 aromatic (face-to-edge)
BU72 V300 6.55x55 TM6 Van der Waals
BU72 V300 6.55x55 TM6 hydrophobic
BU72 W318 7.35x34 TM7 hydrophobic
BU72 W318 7.35x34 TM7 Van der Waals
BU72 I322 7.39x38 TM7 hydrophobic
BU72 I322 7.39x38 TM7 Van der Waals
BU72 Y326 7.43x42 TM7 polar (hydrogen bond)

Ligands

BU72

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x42 7.43x42 Y326