Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8E9X

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-022-05489-0

PUBLICATION DATE

Nov. 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL73538 D112 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL73538 C113 3.33x33 TM3 Van der Waals
CHEMBL73538 S116 3.36x36 TM3 Van der Waals
CHEMBL73538 N117 3.37x37 TM3 Van der Waals
CHEMBL73538 W164 4.57x57 TM4 aromatic (edge-to-face)
CHEMBL73538 W164 4.57x57 TM4 Van der Waals
CHEMBL73538 L190 ECL2 hydrophobic
CHEMBL73538 L190 ECL2 Van der Waals
CHEMBL73538 A200 5.43x44 TM5 Van der Waals
CHEMBL73538 A200 5.43x44 TM5 hydrophobic
CHEMBL73538 G203 5.46x461 TM5 Van der Waals
CHEMBL73538 W413 6.48x48 TM6 aromatic (edge-to-face)
CHEMBL73538 W413 6.48x48 TM6 Van der Waals
CHEMBL73538 Y416 6.51x51 TM6 polar (hydrogen bond)
CHEMBL73538 N417 6.52x52 TM6 polar (hydrogen bond)
CHEMBL73538 V420 6.55x55 TM6 Van der Waals
CHEMBL73538 V420 6.55x55 TM6 hydrophobic
CHEMBL73538 Y439 7.39x38 TM7 hydrophobic
CHEMBL73538 Y439 7.39x38 TM7 Van der Waals
CHEMBL73538 C442 7.42x41 TM7 Van der Waals
CHEMBL73538 Y443 7.43x42 TM7 hydrophobic
CHEMBL73538 Y443 7.43x42 TM7 Van der Waals

Ligands

CHEMBL73538

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x32 3.32x32 D112
3x33 3.33x33 Y113
3x36 3.36x36 S116
3x37 3.37x37 N117
TM4
4x57 4.57x57 W164
TM5
5x44 5.43x44 A200
5x461 5.46x461 A203
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
6x52 6.52x52 N417
6x55 6.55x55 V420
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443