Structure information

FFA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8EJC

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2219569120

PUBLICATION DATE

May 24, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fasiglifam P80 3.26x26 TM3 hydrophobic
fasiglifam A83 3.29x29 TM3 hydrophobic
fasiglifam V84 3.30x30 TM3 hydrophobic
fasiglifam F87 3.33x33 TM3 hydrophobic
fasiglifam Y91 3.37x37 TM3 polar (hydrogen bond)
fasiglifam Y91 3.37x37 TM3 Van der Waals
fasiglifam L138 4.57x57 TM4 polar (hydrogen bond with backbone)
fasiglifam L138 4.57x57 TM4 Van der Waals
fasiglifam V141 4.60x60 TM4 Van der Waals
fasiglifam F142 4.61x61 TM4 aromatic (edge-to-face)
fasiglifam F142 4.61x61 TM4 Van der Waals
fasiglifam L158 ECL2 hydrophobic
fasiglifam L158 ECL2 Van der Waals
fasiglifam L171 45.51x51 ECL2 hydrophobic
fasiglifam L171 45.51x51 ECL2 Van der Waals
fasiglifam R183 5.39x40 TM5 Van der Waals
fasiglifam Y240 6.51x51 TM6 polar (hydrogen bond)
fasiglifam Y240 6.51x51 TM6 Van der Waals

Ligands

fasiglifam

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Residue Diagrams

V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7
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ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x26 3.26x26 P80
3x29 3.29x29 A83
3x30 3.30x30 V84
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x57 4.57x57 L138
4x60 4.60x60 V141
4x61 4.61x61 F142
ECL2
45x51 45.51x51 L171
TM5
5x40 5.39x40 R183
TM6
6x51 6.51x51 Y240