Structure information

C3a receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8I95

SPECIES

Homo sapiens

RESOLUTION

2.880

PREFERRED CHAIN

C

REFERENCE

10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
EP54 ligand W88 23.50x50 ECL1 hydrophobic
EP54 ligand P99 3.29x29 TM3 hydrophobic
EP54 ligand I102 3.32x32 TM3 hydrophobic
EP54 ligand I163 ECL2 hydrophobic
EP54 ligand F164 ECL2 hydrophobic
EP54 ligand C172 45.50x50 ECL2 hydrophobic
EP54 ligand Y174 45.52x52 ECL2 Van der Waals
EP54 ligand Y174 45.52x52 ECL2 polar (hydrogen bond with backbone)
EP54 ligand Y174 45.52x52 ECL2 polar (hydrogen bond)
EP54 ligand L333 5.35x36 TM5 hydrophobic
EP54 ligand L333 5.35x36 TM5 Van der Waals
EP54 ligand R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
EP54 ligand Y393 6.51x51 TM6 Van der Waals
EP54 ligand Y393 6.51x51 TM6 polar (hydrogen bond)
EP54 ligand Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
EP54 ligand G397 6.55x55 TM6 polar (hydrogen bond with backbone)
EP54 ligand G397 6.55x55 TM6 Van der Waals
EP54 ligand D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP54 ligand I421 7.39x38 TM7 hydrophobic
EP54 ligand I421 7.39x38 TM7 Van der Waals

Ligands

EP54 ligand

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7
Download: PNG | SVG
ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
C3a receptor
ECL1
23x50 23.50x50 W88
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
ECL2
45x50 45.50x50 C172
45x52 45.52x52 Y174
TM5
5x36 5.35x36 L333
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x38 7.39x38 I421