Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ID3

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ADD6220

PUBLICATION DATE

March 15, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
9-Hydroxyoctadecanoic acid F27 N-term hydrophobic
9-Hydroxyoctadecanoic acid T119 3.33x33 TM3 polar (hydrogen bond)
9-Hydroxyoctadecanoic acid T119 3.33x33 TM3 Van der Waals
9-Hydroxyoctadecanoic acid G122 3.36x36 TM3 Van der Waals
9-Hydroxyoctadecanoic acid I126 3.40x40 TM3 Van der Waals
9-Hydroxyoctadecanoic acid W198 ECL2 Van der Waals
9-Hydroxyoctadecanoic acid D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
9-Hydroxyoctadecanoic acid F211 5.42x43 TM5 hydrophobic
9-Hydroxyoctadecanoic acid F211 5.42x43 TM5 Van der Waals
9-Hydroxyoctadecanoic acid W277 6.48x48 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I280 6.51x51 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I280 6.51x51 TM6 Van der Waals
9-Hydroxyoctadecanoic acid I281 6.52x52 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I284 6.55x55 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I284 6.55x55 TM6 Van der Waals
9-Hydroxyoctadecanoic acid I287 6.58x58 TM6 Van der Waals
9-Hydroxyoctadecanoic acid L288 6.59x59 TM6 Van der Waals
9-Hydroxyoctadecanoic acid F303 7.35x34 TM7 hydrophobic
9-Hydroxyoctadecanoic acid F303 7.35x34 TM7 Van der Waals

Ligands

9-Hydroxyoctadecanoic acid

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM3
3x33 3.33x33 T119
3x36 3.36x36 G122
3x40 3.40x40 I126
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x52 6.52x52 I281
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288
TM7
7x34 7.35x34 F303