Structure information

HCA2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IHI

SPECIES

Homo sapiens

RESOLUTION

3.110

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-41650-7

PUBLICATION DATE

Aug. 30, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid L83 2.60x60 TM2 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid L104 3.29x29 TM3 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid C177 45.50x50 ECL2 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid S179 45.52x52 ECL2 polar (hydrogen bond with backbone)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid S179 45.52x52 ECL2 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F180 ECL2 polar (hydrogen bond with backbone)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F180 ECL2 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F277 7.36x35 TM7 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid Y284 7.43x42 TM7 polar (hydrogen bond)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid Y284 7.43x42 TM7 Van der Waals

Ligands

(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
TM3
3x29 3.29x29 L104
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
45x52 45.52x52 S179
TM7
7x35 7.36x35 F277
7x42 7.43x42 Y284