Structure information

C3a receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8J6D

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

C

REFERENCE

10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
EP141 peptide agonist F77 2.59x59 TM2 hydrophobic
EP141 peptide agonist S78 2.60x60 TM2 polar (hydrogen bond)
EP141 peptide agonist S78 2.60x60 TM2 Van der Waals
EP141 peptide agonist H81 2.63x63 TM2 Van der Waals
EP141 peptide agonist I102 3.32x32 TM3 hydrophobic
EP141 peptide agonist I102 3.32x32 TM3 Van der Waals
EP141 peptide agonist M106 3.36x36 TM3 Van der Waals
EP141 peptide agonist R161 4.64x65 TM4 Van der Waals
EP141 peptide agonist Y174 45.52x52 ECL2 polar (hydrogen bond)
EP141 peptide agonist K175 ECL2 Van der Waals
EP141 peptide agonist R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
EP141 peptide agonist Y393 6.51x51 TM6 polar (hydrogen bond)
EP141 peptide agonist Y393 6.51x51 TM6 Van der Waals
EP141 peptide agonist S400 6.58x58 TM6 polar (hydrogen bond with backbone)
EP141 peptide agonist S400 6.58x58 TM6 Van der Waals
EP141 peptide agonist T403 6.61x61 TM6 polar (hydrogen bond with backbone)
EP141 peptide agonist T403 6.61x61 TM6 Van der Waals
EP141 peptide agonist D404 ECL3 polar (hydrogen bond with backbone)
EP141 peptide agonist D404 ECL3 polar (charge-assisted hydrogen bond)
EP141 peptide agonist P405 ECL3 Van der Waals
EP141 peptide agonist P405 ECL3 hydrophobic
EP141 peptide agonist D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP141 peptide agonist H418 7.36x35 TM7 Van der Waals
EP141 peptide agonist I421 7.39x38 TM7 Van der Waals
EP141 peptide agonist I421 7.39x38 TM7 hydrophobic

Ligands

EP141 peptide agonist

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Residue Diagrams

G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7
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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
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Residue Table


GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x59 2.59x59 F77
2x60 2.60x60 S78
2x63 2.63x63 H81
TM3
3x32 3.32x32 I102
3x36 3.36x36 M106
TM4
4x65 4.64x65 R161
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x58 6.58x58 S400
6x61 6.61x61 T403
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421