Structure information

A3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X17

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-47207-6

PUBLICATION DATE

April 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cl-IB-MECA L91 3.33x33 TM3 hydrophobic
Cl-IB-MECA T94 3.36x36 TM3 polar (hydrogen bond)
Cl-IB-MECA T94 3.36x36 TM3 Van der Waals
Cl-IB-MECA H95 3.37x37 TM3 Van der Waals
Cl-IB-MECA Q167 45.51x51 ECL2 polar (hydrogen bond)
Cl-IB-MECA F168 45.52x52 ECL2 aromatic (face-to-face)
Cl-IB-MECA F168 45.52x52 ECL2 Van der Waals
Cl-IB-MECA V169 ECL2 hydrophobic
Cl-IB-MECA M177 5.38x40 TM5 Van der Waals
Cl-IB-MECA M177 5.38x40 TM5 hydrophobic
Cl-IB-MECA L246 6.51x51 TM6 Van der Waals
Cl-IB-MECA L246 6.51x51 TM6 hydrophobic
Cl-IB-MECA N250 6.55x55 TM6 Van der Waals
Cl-IB-MECA N250 6.55x55 TM6 polar (hydrogen bond)
Cl-IB-MECA L264 7.35x34 TM7 hydrophobic
Cl-IB-MECA L264 7.35x34 TM7 Van der Waals
Cl-IB-MECA I268 7.39x38 TM7 Van der Waals
Cl-IB-MECA I268 7.39x38 TM7 hydrophobic
Cl-IB-MECA H272 7.43x42 TM7 Van der Waals
Cl-IB-MECA H272 7.43x42 TM7 polar (hydrogen bond)

Ligands

Cl-IB-MECA

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Residue Diagrams

V N G V I A C L G I F I E M T I Y T V N 1 V S L A L A D I A V G L V V M P L A I V V 2 A L L S M I S A H T F I L L L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P I F I W T L F S F Y V M Y 5 F L V L F L F A L S W L P L S I I N C I 6 I P N M M S N A H S L L I G M Y L V L 7
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ICL1 P S L Q ICL1ECL1 I T I ECL1ICL2 T V R Y K R V T ICL2ECL2 W N M K L T S E Y H R N V T F L S C Q F V S V M ECL2ICL3 S N S K ICL3ECL3 G E V ECL3N-term M P N N S T A L N-termC-term L D T S I E K N S E C-term S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T H R R I W L A L G L C W L V S F L V G L T P M F G R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L N L E T G A F Y G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K Y L L C V V D S F K E T I L K A C H P S
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Residue Table


GPCRdb(A)
GPCRdb(A)
A3 receptor
TM3
3x33 3.33x33 L91
3x36 3.36x36 T94
3x37 3.37x37 H95
ECL2
45x51 45.51x51 Q167
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x51 6.51x51 L246
6x55 6.55x55 N250
TM7
7x34 7.35x34 L264
7x38 7.39x38 I268
7x42 7.43x42 H272