Structure information

GPR34

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XBI

SPECIES

Homo sapiens

RESOLUTION

3.060

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Dec. 27, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4758243 Y135 3.33x33 TM3 polar (hydrogen bond)
CHEMBL4758243 Y135 3.33x33 TM3 Van der Waals
CHEMBL4758243 M136 3.34x34 TM3 Van der Waals
CHEMBL4758243 M136 3.34x34 TM3 hydrophobic
CHEMBL4758243 I143 3.41x41 TM3 Van der Waals
CHEMBL4758243 I143 3.41x41 TM3 hydrophobic
CHEMBL4758243 L181 4.52x52 TM4 hydrophobic
CHEMBL4758243 L181 4.52x52 TM4 Van der Waals
CHEMBL4758243 A182 4.53x53 TM4 Van der Waals
CHEMBL4758243 A182 4.53x53 TM4 hydrophobic
CHEMBL4758243 G185 4.56x56 TM4 Van der Waals
CHEMBL4758243 F186 4.57x57 TM4 Van der Waals
CHEMBL4758243 F186 4.57x57 TM4 hydrophobic
CHEMBL4758243 M189 4.60x60 TM4 Van der Waals
CHEMBL4758243 M189 4.60x60 TM4 hydrophobic
CHEMBL4758243 F205 45.51x51 ECL2 polar (hydrogen bond with backbone)
CHEMBL4758243 F205 45.51x51 ECL2 Van der Waals
CHEMBL4758243 H206 45.52x52 ECL2 Van der Waals
CHEMBL4758243 R208 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL4758243 E216 5.36x36 TM5 Van der Waals
CHEMBL4758243 F219 5.39x39 TM5 Van der Waals
CHEMBL4758243 F219 5.39x39 TM5 aromatic (edge-to-face)
CHEMBL4758243 N220 5.40x40 TM5 Van der Waals
CHEMBL4758243 L223 5.43x43 TM5 hydrophobic
CHEMBL4758243 L223 5.43x43 TM5 Van der Waals
CHEMBL4758243 R286 6.55x55 TM6 polar (charge-assisted hydrogen bond)
CHEMBL4758243 Y289 6.58x58 TM6 Van der Waals
CHEMBL4758243 N309 7.35x34 TM7 polar (hydrogen bond)
CHEMBL4758243 N309 7.35x34 TM7 Van der Waals
CHEMBL4758243 E310 7.36x35 TM7 polar (charge-assisted hydrogen bond)
CHEMBL4758243 L313 7.39x38 TM7 Van der Waals

Ligands

CHEMBL4758243

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Residue Diagrams

I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7
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ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x33 3.33x33 Y135
3x34 3.34x34 M136
3x41 3.41x41 I143
TM4
4x52 4.52x52 L181
4x53 4.53x53 A182
4x56 4.56x56 G185
4x57 4.57x57 F186
4x60 4.60x60 M189
ECL2
45x51 45.51x51 F205
45x52 45.52x52 H206
TM5
5x36 5.36x36 E216
5x39 5.39x39 F219
5x40 5.40x40 N220
5x43 5.43x43 L223
TM6
6x55 6.55x55 R286
6x58 6.58x58 Y289
TM7
7x34 7.35x34 N309
7x35 7.36x35 E310
7x38 7.39x38 L313