GPCRdb

quinpirole

Agent/drug
Bioactivity

quinpirole

SMILES	CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@H]21
InChIKey	FTSUPYGMFAPCFZ-ZWNOBZJWSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	219.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₂ D₃ D₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.60	5.60	5.60	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	4.00	4.00	4.00	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.80	5.80	5.80	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.77	5.77	5.77	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	4.60	4.60	4.60	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.24	5.48	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.25	5.50	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.75	6.50	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.76	6.52	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.25	5.50	Guide to Pharmacology
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.24	5.48	PDSP Ki database

Showing 1 to 20 of 46 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pEC50	7.32	7.95	8.66	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.32	5.89	7.00	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	5.55	7.53	9.03	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.33	7.46	8.58	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pEC50	7.10	7.93	8.77	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	7.54	7.57	7.60	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	6.73	8.49	10.01	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.57	7.57	7.57	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	7.08	8.00	8.85	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	7.48	7.48	7.48	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.65	5.65	5.65	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.20	5.20	5.20	ChEMBL

Showing 1 to 12 of 12 entries

quinpirole

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₂ D₃ D₄

Compound is not listed as a drug.