S1P4 receptor (s1pr4_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P4 receptor

GENE

S1PR4 (EDG6)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
A
T
G
T
P
V
A
P
10
                   
E
S
C
Q
Q
L
A
A
G
G
20
                   
H
S
R
L
I
V
L
H
Y
N
30
                   
H
S
G
R
L
A
G
R
G
G
40
    TM1          
P
E
D
G
G
L
G
A
L
R
50
                   
G
L
S
V
A
A
S
C
L
V
60
                   
V
L
E
N
L
L
V
L
A
A
70
        ICL1    
I
T
S
H
M
R
S
R
R
W
80
TM2              
V
Y
Y
C
L
V
N
I
T
L
90
                   
S
D
L
L
T
G
A
A
Y
L
100
            ECL1
A
N
V
L
L
S
G
A
R
T
110
      TM3        
F
R
L
A
P
A
Q
W
F
L
120
                   
R
E
G
L
L
F
T
A
L
A
130
                   
A
S
T
F
S
L
L
F
T
A
140
                   
G
E
R
F
A
T
M
V
R
P
150
ICL2       TM4
V
A
E
S
G
A
T
K
T
S
160
                   
R
V
Y
G
F
I
G
L
C
W
170
                   
L
L
A
A
L
L
G
M
L
P
180
      ECL2      
L
L
G
W
N
C
L
C
A
F
190
                   
D
R
C
S
S
L
L
P
L
Y
200
TM5              
S
K
R
Y
I
L
F
C
L
V
210
                   
I
F
A
G
V
L
A
T
I
M
220
                   
G
L
Y
G
A
I
F
R
L
V
230
      ICL3      
Q
A
S
G
Q
K
A
P
R
P
240
TM6              
A
A
R
R
K
A
R
R
L
L
250
                   
K
T
V
L
M
I
L
L
A
F
260
                   
L
V
C
W
G
P
L
F
G
L
270
                   
L
L
A
D
V
F
G
S
N
L
280
ECL3 TM7      
W
A
Q
E
Y
L
R
G
M
D
290
                   
W
I
L
A
L
A
V
L
N
S
300
                   
A
V
N
P
I
I
Y
S
F
R
310
H8                
S
R
E
V
C
R
A
V
L
S
320
      C-term  
F
L
C
C
G
C
L
R
L
G
330
                   
M
R
G
P
G
D
C
L
A
R
340
                   
A
V
E
A
H
S
G
A
S
T
350
                   
T
D
S
S
L
R
P
R
D
S
360
                   
F
R
G
S
R
S
L
S
F
R
370
                   
M
R
E
P
L
S
S
I
S
S
380
       
V
R
S
I

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 M R S R ICL1ECL1 G A R T F R L ECL1ICL2 P V A E S G A T ICL2ECL2 W N C L C A F D R C S S L L P L Y ECL2ICL3 G Q K A P ICL3ECL3 S N L W A Q ECL3N-term M N A T G T P V A P E S C Q Q L A A G G H S R L I V L H Y N H S G R L A G R G G P E N-termC-term C G C L R L G M R G P G D C L A R A V E A H S G A S T T D S S L R P R D S F R G S R S L S F R M R E P L S S I S S V R S I C-term D G G L G A L R G L S V A A S C L V V L E N L L V L A A I T S H R W V Y Y C L V N I T L S D L L T G A A Y L A N V L L S A P A Q W F L R E G L L F T A L A A S T F S L L F T A G E R F A T M V R K T S R V Y G F I G L C W L L A A L L G M L P L L G S K R Y I L F C L V I F A G V L A T I M G L Y G A I F R L V Q A S R P A A R R K A R R L L K T V L M I L L A F L V C W G P L F G L L L A D V F G E Y L R G M D W I L A L A V L N S A V N P I I Y S F R S R E V L S V C R A F L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V V L C S A A V S L G R L A G L 1 V N I T L S D L L T G A A Y L A N V L L 2 F L L S F T S A A L A T F L L G E R L F 3 V Y G F I G L C W L L A A L L G M L P L 4 Y L G M I T A L V G A F I V L C F L I Y 5 L M I L L A F L V C W G P L F G L L L A 6 I P N V A S N L V A L A L I W D M G R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate

STRUCTURE MODELS

s1pr4_human inactive,

s1pr4_human active

STRUCTURES

No structures available