α1D-adrenoceptor (ada1d_rat)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors α1D-adrenoceptor
GENE
Adra1d (Adra1a)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Alpha-1D adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor, RA42
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
F
|
R
|
D
|
I
|
L
|
S
|
V
|
T
|
10 |
F
|
E
|
G
|
P
|
R
|
S
|
S
|
S
|
S
|
T
|
20 |
G
|
G
|
S
|
G
|
A
|
G
|
G
|
G
|
A
|
G
|
30 |
T
|
V
|
G
|
P
|
E
|
G
|
G
|
A
|
V
|
G
|
40 |
G
|
V
|
P
|
G
|
A
|
T
|
G
|
G
|
G
|
A
|
50 |
V
|
V
|
G
|
T
|
G
|
S
|
G
|
E
|
D
|
N
|
60 |
Q
|
S
|
S
|
T
|
G
|
E
|
P
|
G
|
A
|
A
|
70 |
A
|
S
|
G
|
E
|
V
|
N
|
G
|
S
|
A
|
A
|
80 |
TM1 | |||||||||
V
|
G
|
G
|
L
|
V
|
V
|
S
|
A
|
Q
|
G
|
90 |
V
|
G
|
V
|
G
|
V
|
F
|
L
|
A
|
A
|
F
|
100 |
I
|
L
|
T
|
A
|
V
|
A
|
G
|
N
|
L
|
L
|
110 |
V
|
I
|
L
|
S
|
V
|
A
|
C
|
N
|
R
|
H
|
120 |
ICL1 | TM2 | ||||||||
L
|
Q
|
T
|
V
|
T
|
N
|
Y
|
F
|
I
|
V
|
130 |
N
|
L
|
A
|
V
|
A
|
D
|
L
|
L
|
L
|
S
|
140 |
A
|
A
|
V
|
L
|
P
|
F
|
S
|
A
|
T
|
M
|
150 |
ECL1 | |||||||||
E
|
V
|
L
|
G
|
F
|
W
|
A
|
F
|
G
|
R
|
160 |
TM3 | |||||||||
T
|
F
|
C
|
D
|
V
|
W
|
A
|
A
|
V
|
D
|
170 |
V
|
L
|
C
|
C
|
T
|
A
|
S
|
I
|
L
|
S
|
180 |
L
|
C
|
T
|
I
|
S
|
V
|
D
|
R
|
Y
|
V
|
190 |
ICL2 | |||||||||
G
|
V
|
R
|
H
|
S
|
L
|
K
|
Y
|
P
|
A
|
200 |
TM4 | |||||||||
I
|
M
|
T
|
E
|
R
|
K
|
A
|
A
|
A
|
I
|
210 |
L
|
A
|
L
|
L
|
W
|
A
|
V
|
A
|
L
|
V
|
220 |
V
|
S
|
V
|
G
|
P
|
L
|
L
|
G
|
W
|
K
|
230 |
ECL2 | |||||||||
E
|
P
|
V
|
P
|
P
|
D
|
E
|
R
|
F
|
C
|
240 |
TM5 | |||||||||
G
|
I
|
T
|
E
|
E
|
V
|
G
|
Y
|
A
|
I
|
250 |
F
|
S
|
S
|
V
|
C
|
S
|
F
|
Y
|
L
|
P
|
260 |
M
|
A
|
V
|
I
|
V
|
V
|
M
|
Y
|
C
|
R
|
270 |
V
|
Y
|
V
|
V
|
A
|
R
|
S
|
T
|
T
|
R
|
280 |
ICL3 | |||||||||
S
|
L
|
E
|
A
|
G
|
I
|
K
|
R
|
E
|
P
|
290 |
G
|
K
|
A
|
S
|
E
|
V
|
V
|
L
|
R
|
I
|
300 |
H
|
C
|
R
|
G
|
A
|
A
|
T
|
S
|
A
|
K
|
310 |
G
|
Y
|
P
|
G
|
T
|
Q
|
S
|
S
|
K
|
G
|
320 |
H
|
T
|
L
|
R
|
S
|
S
|
L
|
S
|
V
|
R
|
330 |
TM6 | |||||||||
L
|
L
|
K
|
F
|
S
|
R
|
E
|
K
|
K
|
A
|
340 |
A
|
K
|
T
|
L
|
A
|
I
|
V
|
V
|
G
|
V
|
350 |
F
|
V
|
L
|
C
|
W
|
F
|
P
|
F
|
F
|
F
|
360 |
V
|
L
|
P
|
L
|
G
|
S
|
L
|
F
|
P
|
Q
|
370 |
ECL3 | TM7 | ||||||||
L
|
K
|
P
|
S
|
E
|
G
|
V
|
F
|
K
|
V
|
380 |
I
|
F
|
W
|
L
|
G
|
Y
|
F
|
N
|
S
|
C
|
390 |
V
|
N
|
P
|
L
|
I
|
Y
|
P
|
C
|
S
|
S
|
400 |
H8 | |||||||||
R
|
E
|
F
|
K
|
R
|
A
|
F
|
L
|
R
|
L
|
410 |
C-term | |||||||||
L
|
R
|
C
|
Q
|
C
|
R
|
R
|
R
|
R
|
R
|
420 |
R
|
L
|
W
|
A
|
V
|
Y
|
G
|
H
|
H
|
W
|
430 |
R
|
A
|
S
|
T
|
G
|
D
|
A
|
R
|
S
|
D
|
440 |
C
|
A
|
P
|
S
|
P
|
R
|
I
|
A
|
P
|
P
|
450 |
G
|
A
|
P
|
L
|
A
|
L
|
T
|
A
|
H
|
P
|
460 |
G
|
A
|
G
|
S
|
A
|
D
|
T
|
P
|
E
|
T
|
470 |
Q
|
D
|
S
|
V
|
S
|
S
|
S
|
R
|
K
|
P
|
480 |
A
|
S
|
A
|
L
|
R
|
E
|
W
|
R
|
L
|
L
|
490 |
G
|
P
|
L
|
Q
|
R
|
P
|
T
|
T
|
Q
|
L
|
500 |
R
|
A
|
K
|
V
|
S
|
S
|
L
|
S
|
H
|
K
|
510 |
I
|
R
|
S
|
G
|
A
|
R
|
R
|
A
|
E
|
T
|
520 |
A
|
C
|
A
|
L
|
R
|
S
|
E
|
V
|
E
|
A
|
530 |
V
|
S
|
L
|
N
|
V
|
P
|
Q
|
D
|
G
|
A
|
540 |
E
|
A
|
V
|
I
|
C
|
Q
|
A
|
Y
|
E
|
P
|
550 |
G
|
D
|
Y
|
S
|
N
|
L
|
R
|
E
|
T
|
D
|
560 |
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
(-)-adrenaline, (-)-noradrenaline
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available