β3-adrenoceptor (adrb3_mouse)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors β3-adrenoceptor
GENE
Adrb3 (Adrb3r, B3bar)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
P
|
W
|
P
|
H
|
R
|
N
|
G
|
S
|
10 |
L
|
A
|
L
|
W
|
S
|
D
|
A
|
P
|
T
|
L
|
20 |
TM1 | |||||||||
D
|
P
|
S
|
A
|
A
|
N
|
T
|
S
|
G
|
L
|
30 |
P
|
G
|
V
|
P
|
W
|
A
|
A
|
A
|
L
|
A
|
40 |
G
|
A
|
L
|
L
|
A
|
L
|
A
|
T
|
V
|
G
|
50 |
G
|
N
|
L
|
L
|
V
|
I
|
I
|
A
|
I
|
A
|
60 |
ICL1 | TM2 | ||||||||
R
|
T
|
P
|
R
|
L
|
Q
|
T
|
I
|
T
|
N
|
70 |
V
|
F
|
V
|
T
|
S
|
L
|
A
|
A
|
A
|
D
|
80 |
L
|
V
|
V
|
G
|
L
|
L
|
V
|
M
|
P
|
P
|
90 |
G
|
A
|
T
|
L
|
A
|
L
|
T
|
G
|
H
|
W
|
100 |
ECL1 | TM3 | ||||||||
P
|
L
|
G
|
E
|
T
|
G
|
C
|
E
|
L
|
W
|
110 |
T
|
S
|
V
|
D
|
V
|
L
|
C
|
V
|
T
|
A
|
120 |
S
|
I
|
E
|
T
|
L
|
C
|
A
|
L
|
A
|
V
|
130 |
D
|
R
|
Y
|
L
|
A
|
V
|
T
|
N
|
P
|
L
|
140 |
ICL2 | TM4 | ||||||||
R
|
Y
|
G
|
T
|
L
|
V
|
T
|
K
|
R
|
R
|
150 |
A
|
R
|
A
|
A
|
V
|
V
|
L
|
V
|
W
|
I
|
160 |
V
|
S
|
A
|
A
|
V
|
S
|
F
|
A
|
P
|
I
|
170 |
ECL2 | |||||||||
M
|
S
|
Q
|
W
|
W
|
R
|
V
|
G
|
A
|
D
|
180 |
A
|
E
|
A
|
Q
|
E
|
C
|
H
|
S
|
N
|
P
|
190 |
TM5 | |||||||||
R
|
C
|
C
|
S
|
F
|
A
|
S
|
N
|
M
|
P
|
200 |
Y
|
A
|
L
|
L
|
S
|
S
|
S
|
V
|
S
|
F
|
210 |
Y
|
L
|
P
|
L
|
L
|
V
|
M
|
L
|
F
|
V
|
220 |
Y
|
A
|
R
|
V
|
F
|
V
|
V
|
A
|
K
|
R
|
230 |
Q
|
R
|
H
|
L
|
L
|
R
|
R
|
E
|
L
|
G
|
240 |
ICL3 | |||||||||
R
|
F
|
S
|
P
|
E
|
E
|
S
|
P
|
P
|
S
|
250 |
P
|
S
|
R
|
S
|
P
|
S
|
P
|
A
|
T
|
G
|
260 |
G
|
T
|
P
|
A
|
A
|
P
|
D
|
G
|
V
|
P
|
270 |
TM6 | |||||||||
P
|
C
|
G
|
R
|
R
|
P
|
A
|
R
|
L
|
L
|
280 |
P
|
L
|
R
|
E
|
H
|
R
|
A
|
L
|
R
|
T
|
290 |
L
|
G
|
L
|
I
|
M
|
G
|
I
|
F
|
S
|
L
|
300 |
C
|
W
|
L
|
P
|
F
|
F
|
L
|
A
|
N
|
V
|
310 |
ECL3 | |||||||||
L
|
R
|
A
|
L
|
A
|
G
|
P
|
S
|
L
|
V
|
320 |
TM7 | |||||||||
P
|
S
|
G
|
V
|
F
|
I
|
A
|
L
|
N
|
W
|
330 |
L
|
G
|
Y
|
A
|
N
|
S
|
A
|
F
|
N
|
P
|
340 |
H8 | |||||||||
V
|
I
|
Y
|
C
|
R
|
S
|
P
|
D
|
F
|
R
|
350 |
D
|
A
|
F
|
R
|
R
|
L
|
L
|
C
|
S
|
Y
|
360 |
C-term | |||||||||
G
|
G
|
R
|
G
|
P
|
E
|
E
|
P
|
R
|
A
|
370 |
V
|
T
|
F
|
P
|
A
|
S
|
P
|
V
|
E
|
A
|
380 |
R
|
Q
|
S
|
P
|
P
|
L
|
N
|
R
|
F
|
D
|
390 |
G
|
Y
|
E
|
G
|
A
|
R
|
P
|
F
|
P
|
T
|
400 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
(±)-adrenaline, (-)-adrenaline, (+)-adrenaline, (-)-noradrenaline
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available