AT1 receptor (agtr1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Angiotensin receptors AT1 receptor
GENE
AGTR1 (AGTR1A, AGTR1B, AT2R1, AT2R1B)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
I
|
L
|
N
|
S
|
S
|
T
|
E
|
D
|
G
|
10 |
I
|
K
|
R
|
I
|
Q
|
D
|
D
|
C
|
P
|
K
|
20 |
TM1 | |||||||||
A
|
G
|
R
|
H
|
N
|
Y
|
I
|
F
|
V
|
M
|
30 |
I
|
P
|
T
|
L
|
Y
|
S
|
I
|
I
|
F
|
V
|
40 |
V
|
G
|
I
|
F
|
G
|
N
|
S
|
L
|
V
|
V
|
50 |
ICL1 | |||||||||
I
|
V
|
I
|
Y
|
F
|
Y
|
M
|
K
|
L
|
K
|
60 |
TM2 | |||||||||
T
|
V
|
A
|
S
|
V
|
F
|
L
|
L
|
N
|
L
|
70 |
A
|
L
|
A
|
D
|
L
|
C
|
F
|
L
|
L
|
T
|
80 |
L
|
P
|
L
|
W
|
A
|
V
|
Y
|
T
|
A
|
M
|
90 |
ECL1 | TM3 | ||||||||
E
|
Y
|
R
|
W
|
P
|
F
|
G
|
N
|
Y
|
L
|
100 |
C
|
K
|
I
|
A
|
S
|
A
|
S
|
V
|
S
|
F
|
110 |
N
|
L
|
Y
|
A
|
S
|
V
|
F
|
L
|
L
|
T
|
120 |
C
|
L
|
S
|
I
|
D
|
R
|
Y
|
L
|
A
|
I
|
130 |
ICL2 | |||||||||
V
|
H
|
P
|
M
|
K
|
S
|
R
|
L
|
R
|
R
|
140 |
TM4 | |||||||||
T
|
M
|
L
|
V
|
A
|
K
|
V
|
T
|
C
|
I
|
150 |
I
|
I
|
W
|
L
|
L
|
A
|
G
|
L
|
A
|
S
|
160 |
L
|
P
|
A
|
I
|
I
|
H
|
R
|
N
|
V
|
F
|
170 |
ECL2 | |||||||||
F
|
I
|
E
|
N
|
T
|
N
|
I
|
T
|
V
|
C
|
180 |
A
|
F
|
H
|
Y
|
E
|
S
|
Q
|
N
|
S
|
T
|
190 |
TM5 | |||||||||
L
|
P
|
I
|
G
|
L
|
G
|
L
|
T
|
K
|
N
|
200 |
I
|
L
|
G
|
F
|
L
|
F
|
P
|
F
|
L
|
I
|
210 |
I
|
L
|
T
|
S
|
Y
|
T
|
L
|
I
|
W
|
K
|
220 |
ICL3 | |||||||||
A
|
L
|
K
|
K
|
A
|
Y
|
E
|
I
|
Q
|
K
|
230 |
TM6 | |||||||||
N
|
K
|
P
|
R
|
N
|
D
|
D
|
I
|
F
|
K
|
240 |
I
|
I
|
M
|
A
|
I
|
V
|
L
|
F
|
F
|
F
|
250 |
F
|
S
|
W
|
I
|
P
|
H
|
Q
|
I
|
F
|
T
|
260 |
F
|
L
|
D
|
V
|
L
|
I
|
Q
|
L
|
G
|
I
|
270 |
ECL3 | TM7 | ||||||||
I
|
R
|
D
|
C
|
R
|
I
|
A
|
D
|
I
|
V
|
280 |
D
|
T
|
A
|
M
|
P
|
I
|
T
|
I
|
C
|
I
|
290 |
A
|
Y
|
F
|
N
|
N
|
C
|
L
|
N
|
P
|
L
|
300 |
H8 | |||||||||
F
|
Y
|
G
|
F
|
L
|
G
|
K
|
K
|
F
|
K
|
310 |
R
|
Y
|
F
|
L
|
Q
|
L
|
L
|
K
|
Y
|
I
|
320 |
C-term | |||||||||
P
|
P
|
K
|
A
|
K
|
S
|
H
|
S
|
N
|
L
|
330 |
S
|
T
|
K
|
M
|
S
|
T
|
L
|
S
|
Y
|
R
|
340 |
P
|
S
|
D
|
N
|
V
|
S
|
S
|
S
|
T
|
K
|
350 |
K
|
P
|
A
|
P
|
C
|
F
|
E
|
V
|
E
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
angiotensin III, angiotensin A, angiotensin IV, angiotensin II