5-HT5A receptor (5ht5a_mouse)

FAMILY

Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT5A receptor

GENE

Htr5a (5ht5a)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

5-hydroxytryptamine receptor 5A, 5-HT-5, 5-HT-5A, 5-HT5A, Serotonin receptor 5A

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
L
P
V
N
L
T
S
F
10
                   
S
L
S
T
P
S
S
L
E
P
20
                   
N
R
S
L
D
T
E
V
L
R
30
          TM1    
P
S
R
P
F
L
S
A
F
R
40
                   
V
L
V
L
T
L
L
G
F
L
50
                   
A
A
A
T
F
T
W
N
L
L
60
                   
V
L
A
T
I
L
K
V
R
T
70
ICL1 TM2      
F
H
R
V
P
H
N
L
V
A
80
                   
S
M
A
I
S
D
V
L
V
A
90
                   
V
L
V
M
P
L
S
L
V
H
100
        ECL1    
E
L
S
G
R
R
W
Q
L
G
110
TM3              
R
R
L
C
Q
L
W
I
A
C
120
                   
D
V
L
C
C
T
A
S
I
W
130
                   
N
V
T
A
I
A
L
D
R
Y
140
          ICL2  
W
S
I
T
R
H
L
E
Y
T
150
TM4              
L
R
T
R
K
R
V
S
N
V
160
                   
M
I
L
L
T
W
A
L
S
T
170
                   
V
I
S
L
A
P
L
L
F
G
180
ECL2            
W
G
E
T
Y
S
E
P
S
E
190
            TM5  
E
C
Q
V
S
R
E
P
S
Y
200
                   
T
V
F
S
T
V
G
A
F
Y
210
                   
L
P
L
C
V
V
L
F
V
Y
220
                   
W
K
I
Y
R
A
A
K
F
R
230
                   
M
G
S
R
K
T
N
S
V
S
240
ICL3            
P
V
P
E
A
V
E
V
K
N
250
                   
A
T
Q
H
P
Q
M
V
F
T
260
                   
V
R
H
A
T
V
T
F
Q
T
270
      TM6        
E
G
D
T
W
R
E
Q
K
E
280
                   
Q
R
A
A
L
M
V
G
I
L
290
                   
I
G
V
F
V
L
C
W
F
P
300
                   
F
F
V
T
E
L
I
S
P
L
310
  ECL3 TM7    
C
S
W
D
V
P
A
I
W
K
320
                   
S
I
F
L
W
L
G
Y
S
N
330
                   
S
F
F
N
P
L
I
Y
T
A
340
  H8              
F
N
R
S
Y
S
S
A
F
K
350
      C-term
V
F
F
S
K
Q
Q

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H L E Y T ICL2ECL2 W G E T Y S E P S E E C Q V S R ECL2ICL3 V S P V P E A V E V K N A T Q H P Q M V F T V R H A T V T F Q T E G D ICL3ECL3 S W D V ECL3N-term M D L P V N L T S F S L S T P S S L E P N R S L D T E V L R P S R P F N-termC-term S K Q Q C-term L S A F R V L V L T L L G F L A A A T F T W N L L V L A T I L K V R V P H N L V A S M A I S D V L V A V L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K R V S N V M I L L T W A L S T V I S L A P L L F G E P S Y T V F S T V G A F Y L P L C V V L F V Y W K I Y R A A K F R M G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W F P F F V T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N R S F K V Y S S A F F
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N W T F T A A A L F G L L T L V L V R 1 A S M A I S D V L V A L V V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I L L T W A L S T V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V T Y 5 G I L I G V F V L C W F P F F V T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available