EP1 receptor (pe2r1_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP1 receptor

GENE

Ptger1 (Ptgerep1)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
S
P
C
G
L
N
L
S
L
10
                   
A
D
E
A
A
T
C
A
T
P
20
                   
R
L
P
N
T
S
V
V
L
P
30
            TM1  
T
G
D
N
G
T
S
P
A
L
40
                   
P
I
F
S
M
T
L
G
A
V
50
                   
S
N
V
L
A
L
A
L
L
A
60
      ICL1 TM2
Q
V
A
G
R
M
R
R
R
R
70
                   
S
A
A
T
F
L
L
F
V
A
80
                   
S
L
L
A
I
D
L
A
G
H
90
                   
V
I
P
G
A
L
V
L
R
L
100
    ECL1        
Y
T
A
G
R
A
P
A
G
G
110
TM3              
A
C
H
F
L
G
G
C
M
V
120
                   
F
F
G
L
C
P
L
L
L
G
130
                   
C
G
M
A
V
E
R
C
V
G
140
      ICL2      
V
T
Q
P
L
I
H
A
A
R
150
  TM4            
V
S
V
A
R
A
R
L
A
L
160
                   
A
V
L
A
A
M
A
L
A
V
170
                   
A
L
L
P
L
V
H
V
G
R
180
ECL2            
Y
E
L
Q
Y
P
G
T
W
C
190
                   
F
I
S
L
G
P
R
G
G
W
200
TM5              
R
Q
A
L
L
A
G
L
F
A
210
                   
G
L
G
L
A
A
L
L
A
A
220
                   
L
V
C
N
T
L
S
G
L
A
230
                   
L
L
R
A
R
W
R
R
R
R
240
    ICL3        
S
R
R
F
R
K
T
A
G
P
250
                   
D
D
R
R
R
W
G
S
R
G
260
                   
P
R
L
A
S
A
S
S
A
S
270
                   
S
I
T
S
A
T
A
T
L
R
280
                   
S
S
R
G
G
G
S
A
R
R
290
TM6              
V
H
A
H
D
V
E
M
V
G
300
                   
Q
L
V
G
I
M
V
V
S
C
310
                   
I
C
W
S
P
L
L
V
L
V
320
            ECL3
V
L
A
I
G
G
W
N
S
N
330
  TM7            
S
L
Q
R
P
L
F
L
A
V
340
                   
R
L
A
S
W
N
Q
I
L
D
350
              H8  
P
W
V
Y
I
L
L
R
Q
A
360
                   
M
L
R
Q
L
L
R
L
L
P
370
                   
L
R
V
S
A
K
G
G
P
T
380
C-term        
E
L
G
L
T
K
S
A
W
E
390
                   
A
S
S
L
R
S
S
R
H
S
400
         
G
F
S
H
L

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 G R M R ICL1ECL1 A G R A P A ECL1ICL2 P L I H A A R V ICL2ECL2 V G R Y E L Q Y P G T W C F I S L G P R G ECL2ICL3 R F R K T A G P D D R R R W G S R G P R L A S A S S A S S I T S A T A T L R S S R G G G S A ICL3ECL3 W N S N S ECL3N-term M S P C G L N L S L A D E A A T C A T P R L P N T S V V L P T G D N G T N-termC-term G P T E L G L T K S A W E A S S L R S S R H S G F S H L C-term S P A L P I F S M T L G A V S N V L A L A L L A Q V A R R R S A A T F L L F V A S L L A I D L A G H V I P G A L V L R L Y T G G A C H F L G G C M V F F G L C P L L L G C G M A V E R C V G V T Q S V A R A R L A L A V L A A M A L A V A L L P L V H G W R Q A L L A G L F A G L G L A A L L A A L V C N T L S G L A L L R A R W R R R R S R R R V H A H D V E M V G Q L V G I M V V S C I C W S P L L V L V V L A I G G L Q R P L F L A V R L A S W N Q I L D P W V Y I L L R Q A L L R R V S M L R Q L L P L A K G
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N S V A G L T M S F I P L A P S 1 A S L L A I D L A G H V I P G A L V L R 2 G C G L L L P C L G F F V M C G G L F H 3 A R L A L A V L A A M A L A V A L L P L 4 L T N C V L A A L L A A L G L G A F L G 5 V G I M V V S C I C W S P L L V L V V L 6 W P D L I Q N W S A L R V A L F L P R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

PGF2α, PGE2, PGE1

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available