NPBW1 receptor (npbw1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide W/neuropeptide B receptors NPBW1 receptor
GENE
NPBWR1 (GPR7)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptides B/W receptor type 1, G-protein coupled receptor 7
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
N
|
A
|
S
|
F
|
S
|
E
|
P
|
W
|
10 |
P
|
A
|
N
|
A
|
S
|
G
|
P
|
D
|
P
|
A
|
20 |
L
|
S
|
C
|
S
|
N
|
A
|
S
|
T
|
L
|
A
|
30 |
TM1 | |||||||||
P
|
L
|
P
|
A
|
P
|
L
|
A
|
V
|
A
|
V
|
40 |
P
|
V
|
V
|
Y
|
A
|
V
|
I
|
C
|
A
|
V
|
50 |
G
|
L
|
A
|
G
|
N
|
S
|
A
|
V
|
L
|
Y
|
60 |
ICL1 | |||||||||
V
|
L
|
L
|
R
|
A
|
P
|
R
|
M
|
K
|
T
|
70 |
TM2 | |||||||||
V
|
T
|
N
|
L
|
F
|
I
|
L
|
N
|
L
|
A
|
80 |
I
|
A
|
D
|
E
|
L
|
F
|
T
|
L
|
V
|
L
|
90 |
P
|
I
|
N
|
I
|
A
|
D
|
F
|
L
|
L
|
R
|
100 |
ECL1 | TM3 | ||||||||
Q
|
W
|
P
|
F
|
G
|
E
|
L
|
M
|
C
|
K
|
110 |
L
|
I
|
V
|
A
|
I
|
D
|
Q
|
Y
|
N
|
T
|
120 |
F
|
S
|
S
|
L
|
Y
|
F
|
L
|
T
|
V
|
M
|
130 |
S
|
A
|
D
|
R
|
Y
|
L
|
V
|
V
|
L
|
A
|
140 |
ICL2 | |||||||||
T
|
A
|
E
|
S
|
R
|
R
|
V
|
A
|
G
|
R
|
150 |
TM4 | |||||||||
T
|
Y
|
S
|
A
|
A
|
R
|
A
|
V
|
S
|
L
|
160 |
A
|
V
|
W
|
G
|
I
|
V
|
T
|
L
|
V
|
V
|
170 |
L
|
P
|
F
|
A
|
V
|
F
|
A
|
R
|
L
|
D
|
180 |
ECL2 | |||||||||
D
|
E
|
Q
|
G
|
R
|
R
|
Q
|
C
|
V
|
L
|
190 |
TM5 | |||||||||
V
|
F
|
P
|
Q
|
P
|
E
|
A
|
F
|
W
|
W
|
200 |
R
|
A
|
S
|
R
|
L
|
Y
|
T
|
L
|
V
|
L
|
210 |
G
|
F
|
A
|
I
|
P
|
V
|
S
|
T
|
I
|
C
|
220 |
V
|
L
|
Y
|
T
|
T
|
L
|
L
|
C
|
R
|
L
|
230 |
ICL3 | |||||||||
H
|
A
|
M
|
R
|
L
|
D
|
S
|
H
|
A
|
K
|
240 |
TM6 | |||||||||
A
|
L
|
E
|
R
|
A
|
K
|
K
|
R
|
V
|
T
|
250 |
F
|
L
|
V
|
V
|
A
|
I
|
L
|
A
|
V
|
C
|
260 |
L
|
L
|
C
|
W
|
T
|
P
|
Y
|
H
|
L
|
S
|
270 |
T
|
V
|
V
|
A
|
L
|
T
|
T
|
D
|
L
|
P
|
280 |
ECL3 | TM7 | ||||||||
Q
|
T
|
P
|
L
|
V
|
I
|
A
|
I
|
S
|
Y
|
290 |
F
|
I
|
T
|
S
|
L
|
S
|
Y
|
A
|
N
|
S
|
300 |
C
|
L
|
N
|
P
|
F
|
L
|
Y
|
A
|
F
|
L
|
310 |
H8 | |||||||||
D
|
A
|
S
|
F
|
R
|
R
|
N
|
L
|
R
|
Q
|
320 |
C-term | ||||||||
L
|
I
|
T
|
C
|
R
|
A
|
A
|
A
|
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neuropeptide W-23, des-Br-neuropeptide B-29, neuropeptide B-23, des-Br-neuropeptide B-23, neuropeptide B-29, neuropeptide W-30
STRUCTURE MODELS
STRUCTURES
No structures available