HCA3 receptor (hcar3_human)

FAMILY

Class A (Rhodopsin) Alicarboxylic acid receptors Hydroxycarboxylic acid receptors HCA3 receptor

GENE

HCAR3 (GPR109B, HCA3, HM74B, NIACR2)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
R
H
H
L
Q
D
H
F
10
                   
L
E
I
D
K
K
N
C
C
V
20
    TM1          
F
R
D
D
F
I
A
K
V
L
30
                   
P
P
V
L
G
L
E
F
I
F
40
                   
G
L
L
G
N
G
L
A
L
W
50
          ICL1  
I
F
C
F
H
L
K
S
W
K
60
TM2              
S
S
R
I
F
L
F
N
L
A
70
                   
V
A
D
F
L
L
I
I
C
L
80
                   
P
F
V
M
D
Y
Y
V
R
R
90
ECL1   TM3    
S
D
W
K
F
G
D
I
P
C
100
                   
R
L
V
L
F
M
F
A
M
N
110
                   
R
Q
G
S
I
I
F
L
T
V
120
                   
V
A
V
D
R
Y
F
R
V
V
130
  ICL2          
H
P
H
H
A
L
N
K
I
S
140
TM4              
N
W
T
A
A
I
I
S
C
L
150
                   
L
W
G
I
T
V
G
L
T
V
160
            ECL2
H
L
L
K
K
K
L
L
I
Q
170
                   
N
G
T
A
N
V
C
I
S
F
180
            TM5  
S
I
C
H
T
F
R
W
H
E
190
                   
A
M
F
L
L
E
F
F
L
P
200
                   
L
G
I
I
L
F
C
S
A
R
210
                   
I
I
W
S
L
R
Q
R
Q
M
220
ICL3 TM6      
D
R
H
A
K
I
K
R
A
I
230
                   
T
F
I
M
V
V
A
I
V
F
240
                   
V
I
C
F
L
P
S
V
V
V
250
                   
R
I
H
I
F
W
L
L
H
T
260
  ECL3     TM7
S
G
T
Q
N
C
E
V
Y
R
270
                   
S
V
D
L
A
F
F
I
T
L
280
                   
S
F
T
Y
M
N
S
M
L
D
290
              H8  
P
V
V
Y
Y
F
S
S
P
S
300
                   
F
P
N
F
F
S
T
L
I
N
310
C-term        
R
C
L
Q
R
K
I
T
G
E
320
                   
P
D
N
N
R
S
T
S
V
E
330
                   
L
T
G
D
P
N
K
T
R
G
340
                   
A
P
E
A
L
I
A
N
S
G
350
                   
E
P
W
S
P
S
Y
L
G
P
360
                   
T
S
N
N
H
S
K
K
G
H
370
                   
C
H
Q
E
P
A
S
L
E
K
380
             
Q
L
G
C
C
I
E

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

3-hydroxyoctanoic acid

STRUCTURE MODELS

hcar3_human active,

hcar3_human inactive

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 8IHJ, 8IHK