QRFP receptor (qrfpr_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Peptide P518 receptors QRFP receptor
GENE
Qrfpr (Gpr103)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Pyroglutamylated RF-amide peptide receptor, AQ27, G-protein coupled receptor 103, Orexigenic neuropeptide QRFP receptor, SP9155
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
Q
|
A
|
L
|
N
|
I
|
T
|
A
|
E
|
Q
|
10 |
F
|
S
|
R
|
L
|
L
|
S
|
A
|
H
|
N
|
L
|
20 |
T
|
R
|
E
|
Q
|
F
|
I
|
H
|
R
|
Y
|
G
|
30 |
L
|
R
|
P
|
L
|
V
|
Y
|
T
|
P
|
E
|
L
|
40 |
TM1 | |||||||||
P
|
A
|
R
|
A
|
K
|
V
|
A
|
F
|
A
|
L
|
50 |
A
|
G
|
A
|
L
|
I
|
F
|
A
|
L
|
A
|
L
|
60 |
F
|
G
|
N
|
S
|
L
|
V
|
I
|
Y
|
V
|
V
|
70 |
ICL1 | TM2 | ||||||||
T
|
R
|
S
|
K
|
A
|
M
|
R
|
T
|
V
|
T
|
80 |
N
|
I
|
F
|
I
|
C
|
S
|
L
|
A
|
L
|
S
|
90 |
D
|
L
|
L
|
I
|
A
|
F
|
F
|
C
|
I
|
P
|
100 |
V
|
T
|
M
|
L
|
Q
|
N
|
I
|
S
|
D
|
K
|
110 |
ECL1 | TM3 | ||||||||
W
|
L
|
G
|
G
|
A
|
F
|
I
|
C
|
K
|
M
|
120 |
V
|
P
|
F
|
V
|
Q
|
S
|
T
|
A
|
V
|
V
|
130 |
T
|
E
|
I
|
L
|
T
|
M
|
T
|
C
|
I
|
A
|
140 |
V
|
E
|
R
|
H
|
Q
|
G
|
L
|
V
|
H
|
P
|
150 |
ICL2 | TM4 | ||||||||
F
|
K
|
M
|
K
|
W
|
Q
|
Y
|
T
|
T
|
R
|
160 |
R
|
A
|
F
|
T
|
I
|
L
|
G
|
V
|
V
|
W
|
170 |
L
|
A
|
A
|
I
|
I
|
V
|
G
|
S
|
P
|
M
|
180 |
ECL2 | |||||||||
W
|
H
|
V
|
Q
|
R
|
L
|
E
|
I
|
K
|
Y
|
190 |
D
|
F
|
L
|
Y
|
E
|
K
|
E
|
H
|
I
|
C
|
200 |
TM5 | |||||||||
C
|
L
|
E
|
E
|
W
|
A
|
S
|
P
|
V
|
H
|
210 |
Q
|
R
|
I
|
Y
|
S
|
T
|
F
|
I
|
L
|
V
|
220 |
I
|
L
|
F
|
L
|
L
|
P
|
L
|
V
|
V
|
M
|
230 |
L
|
V
|
L
|
Y
|
S
|
K
|
I
|
G
|
Y
|
E
|
240 |
L
|
W
|
I
|
K
|
K
|
R
|
V
|
G
|
D
|
S
|
250 |
ICL3 | |||||||||
S
|
A
|
L
|
Q
|
T
|
I
|
H
|
G
|
K
|
E
|
260 |
TM6 | |||||||||
M
|
S
|
K
|
I
|
A
|
R
|
K
|
K
|
K
|
R
|
270 |
A
|
V
|
I
|
M
|
M
|
V
|
T
|
V
|
V
|
A
|
280 |
L
|
F
|
A
|
A
|
C
|
W
|
A
|
P
|
F
|
H
|
290 |
V
|
V
|
H
|
M
|
M
|
V
|
E
|
Y
|
S
|
N
|
300 |
ECL3 | TM7 | ||||||||
F
|
E
|
K
|
E
|
Y
|
D
|
D
|
V
|
T
|
I
|
310 |
K
|
M
|
V
|
F
|
A
|
V
|
A
|
Q
|
T
|
I
|
320 |
G
|
F
|
F
|
N
|
S
|
I
|
C
|
N
|
P
|
F
|
330 |
H8 | |||||||||
V
|
Y
|
A
|
F
|
M
|
N
|
E
|
N
|
F
|
K
|
340 |
K
|
N
|
F
|
L
|
S
|
A
|
V
|
C
|
Y
|
C
|
350 |
C-term | |||||||||
I
|
V
|
K
|
E
|
S
|
S
|
S
|
P
|
A
|
R
|
360 |
K
|
P
|
G
|
N
|
S
|
G
|
I
|
S
|
M
|
M
|
370 |
Q
|
K
|
R
|
A
|
K
|
L
|
S
|
R
|
P
|
Q
|
380 |
R
|
P
|
V
|
E
|
E
|
T
|
K
|
G
|
D
|
T
|
390 |
F
|
S
|
D
|
A
|
S
|
I
|
D
|
V
|
K
|
L
|
400 |
C
|
E
|
Q
|
P
|
R
|
E
|
K
|
R
|
Q
|
L
|
410 |
K
|
R
|
Q
|
L
|
A
|
F
|
F
|
S
|
S
|
E
|
420 |
L
|
S
|
E
|
N
|
S
|
T
|
F
|
G
|
S
|
G
|
430 |
H
|
E
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
QRFP26
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available