HCA2 receptor (hcar2_mouse)
FAMILY
Class A (Rhodopsin) Alicarboxylic acid receptors Hydroxycarboxylic acid receptors HCA2 receptor
GENE
Hcar2 (Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109, G-protein coupled receptor 109A, G-protein coupled receptor HM74, Niacin receptor 1, Nicotinic acid receptor, Protein PUMA-G
SOURCE
SWISSPROT
SEQUENCE
| N-term | |||||||||
|
M
|
S
|
K
|
S
|
D
|
H
|
F
|
L
|
V
|
I
|
| 10 | |||||||||
|
N
|
G
|
K
|
N
|
C
|
C
|
V
|
F
|
R
|
D
|
| 20 | |||||||||
| TM1 | |||||||||
|
E
|
N
|
I
|
A
|
K
|
V
|
L
|
P
|
P
|
V
|
| 30 | |||||||||
|
L
|
G
|
L
|
E
|
F
|
V
|
F
|
G
|
L
|
L
|
| 40 | |||||||||
|
G
|
N
|
G
|
L
|
A
|
L
|
W
|
I
|
F
|
C
|
| 50 | |||||||||
| ICL1 | TM2 | ||||||||
|
F
|
H
|
L
|
K
|
S
|
W
|
K
|
S
|
S
|
R
|
| 60 | |||||||||
|
I
|
F
|
L
|
F
|
N
|
L
|
A
|
V
|
A
|
D
|
| 70 | |||||||||
|
F
|
L
|
L
|
I
|
I
|
C
|
L
|
P
|
F
|
L
|
| 80 | |||||||||
|
T
|
D
|
N
|
Y
|
V
|
H
|
N
|
W
|
D
|
W
|
| 90 | |||||||||
| ECL1 | TM3 | ||||||||
|
R
|
F
|
G
|
G
|
I
|
P
|
C
|
R
|
V
|
M
|
| 100 | |||||||||
|
L
|
F
|
M
|
L
|
A
|
M
|
N
|
R
|
Q
|
G
|
| 110 | |||||||||
|
S
|
I
|
I
|
F
|
L
|
T
|
V
|
V
|
A
|
V
|
| 120 | |||||||||
|
D
|
R
|
Y
|
F
|
R
|
V
|
V
|
H
|
P
|
H
|
| 130 | |||||||||
| ICL2 | TM4 | ||||||||
|
H
|
F
|
L
|
N
|
K
|
I
|
S
|
N
|
R
|
T
|
| 140 | |||||||||
|
A
|
A
|
I
|
I
|
S
|
C
|
F
|
L
|
W
|
G
|
| 150 | |||||||||
|
L
|
T
|
I
|
G
|
L
|
T
|
V
|
H
|
L
|
L
|
| 160 | |||||||||
| ECL2 | |||||||||
|
Y
|
T
|
N
|
M
|
M
|
T
|
K
|
N
|
G
|
E
|
| 170 | |||||||||
|
A
|
Y
|
L
|
C
|
S
|
S
|
F
|
S
|
I
|
C
|
| 180 | |||||||||
| TM5 | |||||||||
|
Y
|
N
|
F
|
R
|
W
|
H
|
D
|
A
|
M
|
F
|
| 190 | |||||||||
|
L
|
L
|
E
|
F
|
F
|
L
|
P
|
L
|
A
|
I
|
| 200 | |||||||||
|
I
|
L
|
F
|
C
|
S
|
G
|
R
|
I
|
I
|
W
|
| 210 | |||||||||
| ICL3 | |||||||||
|
S
|
L
|
R
|
Q
|
R
|
Q
|
M
|
D
|
R
|
H
|
| 220 | |||||||||
| TM6 | |||||||||
|
A
|
K
|
I
|
K
|
R
|
A
|
I
|
N
|
F
|
I
|
| 230 | |||||||||
|
M
|
V
|
V
|
A
|
I
|
V
|
F
|
I
|
I
|
C
|
| 240 | |||||||||
|
F
|
L
|
P
|
S
|
V
|
A
|
V
|
R
|
I
|
R
|
| 250 | |||||||||
|
I
|
F
|
W
|
L
|
L
|
Y
|
K
|
Y
|
N
|
V
|
| 260 | |||||||||
| ECL3 | TM7 | ||||||||
|
R
|
N
|
C
|
D
|
I
|
Y
|
S
|
S
|
V
|
D
|
| 270 | |||||||||
|
L
|
A
|
F
|
F
|
T
|
T
|
L
|
S
|
F
|
T
|
| 280 | |||||||||
|
Y
|
M
|
N
|
S
|
M
|
L
|
D
|
P
|
V
|
V
|
| 290 | |||||||||
| H8 | |||||||||
|
Y
|
Y
|
F
|
S
|
S
|
P
|
S
|
F
|
P
|
N
|
| 300 | |||||||||
|
F
|
F
|
S
|
T
|
C
|
I
|
N
|
R
|
C
|
L
|
| 310 | |||||||||
| C-term | |||||||||
|
R
|
K
|
K
|
T
|
L
|
G
|
E
|
P
|
D
|
N
|
| 320 | |||||||||
|
N
|
R
|
S
|
T
|
S
|
V
|
E
|
L
|
T
|
G
|
| 330 | |||||||||
|
D
|
P
|
S
|
T
|
T
|
R
|
S
|
I
|
P
|
G
|
| 340 | |||||||||
|
A
|
L
|
M
|
A
|
D
|
P
|
S
|
E
|
P
|
G
|
| 350 | |||||||||
|
S
|
P
|
P
|
Y
|
L
|
A
|
S
|
T
|
S
|
R
|
| 360 | |||||||||
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'snake_hcar2_mouse.png',
{scale: 3});){kind=link}
, 'snake_hcar2_mouse.jpg',
{scale: 3});){kind=link}
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'helixbox_hcar2_mouse.png',
{scale: 3});){kind=link}
, 'helixbox_hcar2_mouse.jpg',
{scale: 3});){kind=link}
, 'sankey_.png');){kind=link}
, 'sankey_.jpg');){kind=link}
MUTATIONS
PHYSIOLOGICAL LIGANDS
β-D-hydroxybutyric acid
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available