LPA5 receptor (lpar5_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA5 receptor

GENE

LPAR5 (GPR92, GPR93)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Lysophosphatidic acid receptor 5, LPA receptor 5, LPA-5, G-protein coupled receptor 92, G-protein coupled receptor 93

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
L
A
N
S
S
S
T
N
S
10
                   
S
V
L
P
C
P
D
Y
R
P
20
TM1              
T
H
R
L
H
L
V
V
Y
S
30
                   
L
V
L
A
A
G
L
P
L
N
40
                   
A
L
A
L
W
V
F
L
R
A
50
ICL1 TM2      
L
R
V
H
S
V
V
S
V
Y
60
                   
M
C
N
L
A
A
S
D
L
L
70
                   
F
T
L
S
L
P
V
R
L
S
80
        ECL1    
Y
Y
A
L
H
H
W
P
F
P
90
TM3              
D
L
L
C
Q
T
T
G
A
I
100
                   
F
Q
M
N
M
Y
G
S
C
I
110
                   
F
L
M
L
I
N
V
D
R
Y
120
          ICL2  
A
A
I
V
H
P
L
R
L
R
130
      TM4        
H
L
R
R
P
R
V
A
R
L
140
                   
L
C
L
G
V
W
A
L
I
L
150
                   
V
F
A
V
P
A
A
R
V
H
160
ECL2            
R
P
S
R
C
R
Y
R
D
L
170
                   
E
V
R
L
C
F
E
S
F
S
180
    TM5          
D
E
L
W
K
G
R
L
L
P
190
                   
L
V
L
L
A
E
A
L
G
F
200
                   
L
L
P
L
A
A
V
V
Y
S
210
                   
S
G
R
V
F
W
T
L
A
R
220
ICL3 TM6      
P
D
A
T
Q
S
Q
R
R
R
230
                   
K
T
V
R
L
L
L
A
N
L
240
                   
V
I
F
L
L
C
F
V
P
Y
250
                   
N
S
T
L
A
V
Y
G
L
L
260
      ECL3 TM7
R
S
K
L
V
A
A
S
V
P
270
                   
A
R
D
R
V
R
G
V
L
M
280
                   
V
M
V
L
L
A
G
A
N
C
290
                   
V
L
D
P
L
V
Y
Y
F
S
300
H8                
A
E
G
F
R
N
T
L
R
G
310
                   
L
G
T
P
H
R
A
R
T
S
320
C-term        
A
T
N
G
T
R
A
A
L
A
330
                   
Q
S
E
R
S
A
V
T
T
D
340
                   
A
T
R
P
D
A
A
S
Q
G
350
                   
L
L
R
P
S
D
S
H
S
L
360
                   
S
S
F
T
Q
C
P
Q
D
S
370
   
A
L

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 L R V H ICL1ECL1 H H W P F ECL1ICL2 P L R L R H L R ICL2ECL2 R P S R C R Y R D L E V R L C F E S F S D E ECL2ICL3 P D A T ICL3ECL3 L V A A ECL3N-term M L A N S S S T N S S V L P C P D Y N-termC-term R A R T S A T N G T R A A L A Q S E R S A V T T D A T R P D A A S Q G L L R P S D S H S L S S F T Q C P Q D S A L C-term R P T H R L H L V V Y S L V L A A G L P L N A L A L W V F L R A S V V S V Y M C N L A A S D L L F T L S L P V R L S Y Y A L P D L L C Q T T G A I F Q M N M Y G S C I F L M L I N V D R Y A A I V H R P R V A R L L C L G V W A L I L V F A V P A A R V H L W K G R L L P L V L L A E A L G F L L P L A A V V Y S S G R V F W T L A R Q S Q R R R K T V R L L L A N L V I F L L C F V P Y N S T L A V Y G L L R S K S V P A R D R V R G V L M V M V L L A G A N C V L D P L V Y Y F S A E G L R G H F R N T L G T P
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N L P L G A A L V L S Y V V L H L R H 1 C N L A A S D L L F T L S L P V R L S Y 2 L M L F I C S G Y M N M Q F I A G T T Q 3 A R L L C L G V W A L I L V F A V P A 4 S S Y V V A A L P L L F G L A E A L L V L 5 L A N L V I F L L C F V P Y N S T L A V 6 L P D L V C N A G A L L V M V M L V G 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

LYSOPHOSPHATIDIC ACID, LPA, farnesyl diphosphate, farnesyl monophosphate, N-arachidonoylglycine, 1-O-Oleoyl-D-glycerol 3-phosphoric acid

STRUCTURE MODELS

lpar5_human active,

lpar5_human inactive

STRUCTURES

No structures available