GPCRdb

GPR179 (gp179_human)

FAMILY

Class C (Glutamate) Orphan receptors Class C Orphans GPR179

GENE

GPR179 (GPR158L, GPR158L1)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Probable G-protein coupled receptor 179, Probable G-protein coupled receptor 158-like 1, GPR158-like

SOURCE

SWISSPROT

SEQUENCE

N-term
M	G	T	R	G	A	V	M	P	P
10


P	M	W	G	L	L	G	C	C	F
20


V	C	A	W	A	L	G	G	P	R
30


P	I	R	S	L	P	P	L	S	S
40


Q	V	K	P	G	S	V	P	M	Q
50


V	P	L	E	G	A	E	A	A	L
60


A	Y	L	Y	S	G	D	A	Q	Q
70


L	S	Q	V	N	C	S	E	R	Y
80


E	A	R	G	A	G	A	M	P	G
90


L	P	P	S	L	Q	G	A	A	G
100


T	L	A	Q	A	A	N	F	L	N
110


M	L	L	Q	A	N	D	I	R	E
120


S	S	V	E	E	D	V	E	W	Y
130


Q	A	L	V	R	S	V	A	E	G
140


D	P	R	V	Y	R	A	L	L	T
150


F	N	P	P	P	G	A	S	H	L
160


Q	L	A	L	Q	A	T	R	T	G
170


E	E	T	I	L	Q	D	L	S	G
180


N	W	V	Q	E	E	N	P	P	G
190


D	L	D	T	P	A	L	K	K	R
200


V	L	T	N	D	L	G	S	L	G
210


S	P	K	W	P	Q	A	D	G	Y
220


V	G	D	T	Q	Q	V	R	L	S
230


P	P	F	L	E	C	Q	E	G	R
240


L	R	P	G	W	L	I	T	L	S
250


A	T	F	Y	G	L	K	P	D	L
260


S	P	E	V	R	G	Q	V	Q	M
270


D	V	D	L	Q	S	V	D	I	N
280


Q	C	A	S	G	P	G	W	Y	S
290


N	T	H	L	C	D	L	N	S	T
300


Q	C	V	P	L	E	S	Q	G	F
310


V	L	G	R	Y	L	C	R	C	R
320


P	G	F	Y	G	A	S	P	S	G
330


G	L	E	E	S	D	F	Q	T	T
340


G	Q	F	G	F	P	E	G	R	S
350


G	R	L	L	Q	C	L	P	C	P
360


E	G	C	T	S	C	M	D	A	T
370

						TM1
P	C	L	V	E	E	A	A	V	L
380


R	A	A	V	L	A	C	Q	A	C
390


C	M	L	A	I	F	L	S	M	L
400

					ICL1
V	S	Y	R	C	R	R	N	K	R
410

				TM2
I	W	A	S	G	V	V	L	L	E
420


T	V	L	F	G	F	L	L	L	Y
430


F	P	V	F	I	L	Y	F	K	P
440

ECL1				TM3
S	V	F	R	C	I	A	L	R	W
450


V	R	L	L	G	F	A	I	V	Y
460


G	T	I	I	L	K	L	Y	R	V
470


L	Q	L	F	L	S	R	T	A	Q
480

ICL2					TM4
R	S	A	L	L	S	S	G	R	L
490


L	R	R	L	G	L	L	L	L	P
500


V	L	G	F	L	A	V	W	T	V
510

						ECL2
G	A	L	E	R	G	I	Q	H	A
520


P	L	V	I	R	G	H	T	P	S
530


G	R	H	F	Y	L	C	H	H	D
540

TM5
R	W	D	Y	I	M	V	V	A	E
550


L	L	L	L	C	W	G	S	F	L
560

				ICL3
C	Y	A	T	R	A	V	L	S	A
570

	TM6
F	H	E	P	R	Y	M	G	I	A
580


L	H	N	E	L	L	L	S	A	A
590


F	H	T	A	R	F	V	L	V	P
600

ECL3				TM7
S	L	H	P	D	W	T	L	L	L
610


F	F	F	H	T	H	S	T	V	T
620


T	T	L	A	L	I	F	I	P	K
630

							H8
F	W	K	L	G	A	P	P	R	E
640


E	M	V	D	E	V	C	E	D	E
650

C-term
L	D	L	Q	H	S	G	S	Y	L
660


G	S	S	I	A	S	A	W	S	E
670


H	S	L	D	P	G	D	I	R	D
680


E	L	K	K	L	Y	A	Q	L	E
690


V	H	K	T	K	E	M	A	A	N
700


N	P	H	L	P	K	K	R	G	S
710


S	C	Q	G	L	G	R	S	F	M
720


R	Y	L	A	E	F	P	E	A	L
730


A	R	Q	H	S	R	D	S	G	S
740


P	G	H	G	S	L	P	G	S	S
750


R	R	R	L	L	S	S	S	L	Q
760


E	P	E	G	T	P	A	L	H	K
770


S	R	S	T	Y	D	Q	R	R	E
780


Q	D	P	P	L	L	D	S	L	L
790


R	R	K	L	A	K	K	A	S	R
800


T	E	S	R	E	S	V	E	G	P
810


P	A	L	G	F	R	S	A	S	A
820


H	N	L	T	V	G	E	R	L	P
830


R	A	R	P	A	S	L	Q	K	S
840


L	S	V	A	S	S	R	E	K	A
850


L	L	M	A	S	Q	A	Y	L	E
860


E	T	Y	R	Q	A	K	E	R	E
870


E	R	K	K	A	K	A	A	M	A
880


S	L	V	R	R	P	S	A	R	R
890


L	E	R	P	R	G	A	P	L	S
900


A	P	P	S	P	A	K	S	S	S
910


V	D	S	S	H	T	S	G	R	L
920


H	E	E	A	R	R	R	L	P	H
930


P	P	I	R	H	Q	V	S	T	P
940


I	L	A	L	S	G	G	L	G	E
950


P	R	M	L	S	P	T	S	T	L
960


A	P	A	L	L	P	A	L	A	P
970


T	P	A	P	A	L	A	P	V	P
980


V	S	P	Q	S	P	N	L	L	T
990


Y	I	C	P	W	E	N	A	E	L
1000


P	A	K	Q	E	N	V	P	Q	E
1010


G	P	S	G	P	E	R	G	H	H
1020


S	P	A	P	A	R	A	R	L	W
1030


R	A	L	S	V	A	V	E	K	S
1040


R	A	G	E	N	E	M	D	A	E
1050


D	A	H	H	Q	R	E	A	N	D
1060


V	D	E	D	R	P	K	I	F	P
1070


K	S	H	S	L	K	A	P	V	Q
1080


Q	G	S	M	R	S	L	G	L	A
1090


I	K	A	L	T	R	S	R	S	T
1100


Y	R	E	K	E	S	V	E	E	S
1110


P	E	G	Q	N	S	G	T	A	G
1120


E	S	M	G	A	P	S	R	S	P
1130


R	L	G	R	P	K	A	V	S	K
1140


Q	A	A	L	I	P	S	D	D	K
1150


E	S	L	Q	N	Q	Q	N	A	H
1160


T	S	R	M	L	Q	V	C	Q	R
1170


E	G	S	R	E	Q	E	D	R	G
1180


R	R	M	T	Q	G	L	G	E	R
1190


K	A	E	R	A	G	K	T	G	L
1200


A	M	L	R	Q	V	S	R	D	K
1210


N	I	K	Q	S	K	E	T	P	V
1220


G	W	Q	E	L	P	K	A	G	L
1230


Q	S	L	G	S	A	D	H	R	V
1240


A	E	V	C	P	W	E	V	T	E
1250


S	E	T	R	Q	P	D	S	G	N
1260


K	A	E	I	C	P	W	E	T	S
1270


E	G	A	P	E	S	R	A	L	R
1280


Q	D	P	G	D	S	Q	K	K	R
1290


G	E	A	R	G	K	S	E	P	I
1300


D	V	V	P	M	M	R	K	K	P
1310


E	R	L	V	R	E	Q	E	A	V
1320


C	P	W	E	S	A	D	R	G	G
1330


L	S	P	G	S	A	P	Q	D	P
1340


G	R	I	R	D	K	S	E	A	G
1350


D	S	V	E	A	R	K	V	E	K
1360


P	G	W	E	A	A	G	P	E	A
1370


H	T	P	D	I	T	K	A	E	P
1380


C	P	W	E	A	S	E	G	G	E
1390


D	G	K	P	A	Q	E	A	V	K
1400


D	L	P	Q	E	K	Q	K	T	R
1410


K	A	T	F	W	K	E	Q	K	P
1420


G	G	D	L	E	S	L	C	P	W
1430


E	S	T	D	F	R	G	P	S	A
1440


V	S	I	Q	A	P	G	S	S	E
1450


C	S	G	S	L	G	S	G	I	A
1460


E	V	C	L	W	E	A	G	D	A
1470


P	A	I	Q	K	A	E	I	C	P
1480


W	E	L	D	D	N	V	M	G	Q
1490


E	M	L	S	L	G	T	G	R	E
1500


S	L	Q	E	K	E	K	A	S	R
1510


K	G	S	F	G	E	M	G	E	Q
1520


T	V	K	A	V	Q	K	L	S	Q
1530


Q	Q	E	S	V	C	P	R	E	S
1540


T	V	P	G	H	S	S	P	C	L
1550


D	N	S	S	S	K	A	G	S	Q
1560


F	L	C	N	G	G	S	R	A	T
1570


Q	V	C	P	Q	E	D	L	R	P
1580


E	A	Q	E	A	T	P	A	K	T
1590


E	I	C	P	W	E	V	N	E	R
1600


T	R	E	E	W	T	S	A	Q	V
1610


P	R	G	G	E	S	Q	K	D	K
1620


E	K	M	P	G	K	S	E	I	E
1630


D	V	T	A	W	E	K	P	E	G
1640


Q	I	Q	K	Q	E	A	V	G	P
1650


W	E	S	V	D	P	G	S	F	S
1660


P	Q	P	R	P	Q	D	T	E	R
1670


P	Q	T	L	L	Q	M	S	G	S
1680


V	G	S	K	A	A	D	I	C	P
1690


L	D	V	E	E	N	L	T	A	G
1700


K	A	E	I	C	P	W	E	V	G
1710


A	G	A	G	E	E	R	A	L	G
1720


A	E	A	I	R	K	S	P	N	D
1730


T	G	K	V	S	A	D	L	G	P
1740


R	E	R	A	V	T	A	P	E	K
1750


P	Q	K	P	T	P	E	W	E	V
1760


A	C	P	W	G	S	V	G	P	G
1770


A	C	S	Q	H	P	G	T	L	D
1780


A	D	G	P	K	A	G	F	Q	E
1790


L	D	H	M	G	C	R	P	G	E
1800


V	C	P	W	E	A	Q	E	A	A
1810


T	S	E	K	A	K	I	C	P	W
1820


E	V	S	E	G	T	T	G	K	G
1830


L	D	Q	K	A	G	S	E	S	A
1840


E	Q	R	E	K	A	L	E	K	G
1850


R	L	T	S	L	G	E	D	V	S
1860


K	G	M	A	K	L	C	Q	Q	Q
1870


E	T	I	C	I	W	E	N	K	D
1880


L	R	E	S	P	A	Q	A	P	K
1890


I	S	D	L	P	S	S	M	S	S
1900


E	V	A	E	G	H	S	L	E	A
1910


T	E	K	G	D	L	R	Q	D	P
1920


K	T	G	S	F	P	E	H	I	T
1930


Q	E	K	A	P	A	A	D	T	E
1940


E	F	T	T	E	D	G	E	K	T
1950


S	H	E	L	Q	S	V	C	P	W
1960


E	T	T	A	P	A	D	S	V	S
1970


H	L	D	R	Q	R	P	D	Q	P
1980


K	A	S	S	Q	R	L	V	S	T
1990


G	G	R	A	A	D	V	C	P	W
2000


D	V	P	D	A	G	V	Y	K	S
2010


D	S	S	A	K	A	E	T	C	P
2020


W	E	V	T	E	R	I	P	V	K
2030


G	V	S	R	Q	D	G	K	G	D
2040


S	Q	E	E	K	G	R	A	P	E
2050


K	S	E	P	K	G	V	P	V	Q
2060


K	K	P	E	M	A	D	F	R	Q
2070


Q	E	A	V	C	P	W	E	S	Q
2080


D	G	K	G	L	S	P	Q	P	A
2090


P	D	A	S	D	R	S	R	G	S
2100


S	E	A	A	G	S	V	E	T	R
2110


V	A	E	V	C	L	W	E	V	V
2120


E	A	P	S	A	K	K	A	E	I
2130


C	P	W	E	A	G	G	G	A	A
2140


E	E	G	E	Q	E	R	E	S	Q
2150


G	Q	G	E	M	F	L	Q	K	A
2160


G	P	G	G	T	E	E	H	F	S
2170


K	A	A	A	K	P	R	E	Q	E
2180


A	V	C	P	G	E	G	T	G	S
2190


G	G	L	L	P	Q	S	G	A	L
2200


D	P	E	L	K	V	S	P	K	E
2210


A	G	S	M	G	S	R	M	A	E
2220


L	C	Q	W	E	I	T	D	P	E
2230


G	N	K	I	K	G	T	M	A	D
2240


I	C	P	G	E	E	T	G	V	P
2250


S	E	E	S	G	L	L	A	L	T
2260


A	T	R	R	E	F	F	P	T	A
2270


P	E	K	P	L	C	L	L	V	H
2280


G	P	L	D	H	F	F	P	E	S
2290


K	I	P	C	P	K	V	S	R	P
2300


A	S	T	F	T	L	E	G	V	R
2310


E	L	Q	G	P	S	G	L	E	P
2320


R	T	S	L	A	P	E	P	S	L
2330


Q	E	A	E	S	Q	S	S	S	L
2340


T	E	D	S	G	Q	V	A	F	E
2350


A	Q	Y	E	E	F	T	P	P	T
2360


V	Y	P	W	D	W	E

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

Pick color:

Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

Pick color:

Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

gp179_human inactive

STRUCTURES

No structures available

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