GPR68 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8Z68

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

April 23, 2025

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 F 127 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 127 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 127 - G.H5 F 376 G.H5.08
Hydrophobic TM3 D 118 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 127 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 127 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 127 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 127 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 127 - G.H5 R 380 G.H5.12
Hydrophobic TM5 V 212 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM2 L 60 2x43 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 60 2x43 G.H5 E 392 G.H5.24
Polar ICL2 H 130 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 130 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 130 - G.hns1 R 38 G.hns1.02
Polar ICL3 G 217 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 G 217 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 G 217 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 G 217 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 G 217 - G.H5 R 385 G.H5.17
Hydrophobic TM2 L 56 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 56 2x39 G.H5 E 392 G.H5.24
Polar ICL3 H 216 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 H 130 - G.hns1 A 39 G.hns1.03
Polar TM5 A 211 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 211 5x64 G.H5 Q 384 G.H5.16
Polar TM3 R 119 3x50 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 119 3x50 G.H5 E 392 G.H5.24
Van-der-waals TM3 R 119 3x50 G.H5 E 392 G.H5.24
Hydrophobic ICL3 H 216 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 H 216 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 H 216 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 H 216 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 F 127 - G.S3 F 229 G.S3.03
Hydrophobic TM5 I 208 5x61 G.H5 L 393 G.H5.25
Polar ICL3 S 215 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 S 215 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 S 215 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 G 217 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 G 217 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 229 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 229 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 123 3x54 G.H5 L 393 G.H5.25
Hydrophobic H8 S 290 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 290 8x47 G.H5 E 392 G.H5.24
Polar H8 E 291 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 E 291 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 E 291 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Polar TM3 A 124 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 A 124 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 124 3x55 G.H5 R 380 G.H5.12
Polar TM3 A 122 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM2 L 56 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 L 56 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 L 393 G.H5.25
Ionic ICL3 H 216 - G.H5 D 381 G.H5.13
Polar ICL3 H 216 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 H 216 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 H 216 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 T 218 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 T 218 - G.H5 R 385 G.H5.17
Hydrophobic TM6 I 226 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 V 230 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 126 - G.H5 H 387 G.H5.19
Polar ICL2 R 133 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 133 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 133 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 126 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 126 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 G 217 - G.S6 Y 360 G.S6.02
Polar ICL2 R 133 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 133 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 127 - G.S3 V 227 G.S3.01
Polar ICL2 R 133 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 133 - G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 218 - G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 126 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 126 - G.H5 I 383 G.H5.15
Hydrophobic TM6 I 226 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 226 6x33 G.H5 L 394 G.H5.26
Polar TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Polar TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 127 - G.H5 I 383 G.H5.15
Hydrophobic TM6 I 226 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 126 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 126 - G.H5 R 380 G.H5.12
Hydrophobic TM3 V 123 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 127 - G.H5 C 379 G.H5.11
Polar TM2 N 54 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 N 54 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 N 54 2x37 G.H5 Q 390 G.H5.22