Gi3 - 5-HT1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 150 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 150 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 150 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 154 34x50 G.H5 I 343 G.H5.15
Polar TM5 Q 242 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 Q 242 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 Q 242 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 A 312 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 312 6x33 G.H5 L 353 G.H5.25
Polar ICL2 S 158 34x54 G.hns1 A 31 G.hns1.02
Polar TM3 R 147 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL1 R 78 12x48 G.HN L 23 G.HN.47
Hydrophobic TM5 I 239 5x69 G.H5 Y 354 G.H5.26
Hydrophobic TM4 T 162 4x38 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 A 235 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 316 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 316 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 151 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 151 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 A 84 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 A 84 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM4 P 163 4x39 G.HN E 28 G.HN.52
Ionic TM6 R 308 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 308 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 308 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 308 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM7 S 372 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 372 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 372 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 R 238 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 315 6x36 G.H5 L 353 G.H5.25
Polar ICL2 A 159 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 159 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 159 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 159 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 A 159 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 311 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 311 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 311 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 155 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 155 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 R 238 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 238 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 231 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 231 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 304 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 L 304 6x25 G.h4s6 K 314 G.h4s6.08
Ionic TM5 K 241 5x71 G.H5 D 341 G.H5.13
Polar TM5 K 241 5x71 G.H5 D 341 G.H5.13
Hydrophobic ICL2 S 158 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 304 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 I 151 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 151 3x54 G.H5 L 353 G.H5.25
Ionic ICL3 K 249 - G.H4 E 308 G.H4.16
Polar ICL3 K 249 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 K 249 - G.H4 E 308 G.H4.16
Polar TM6 R 308 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 308 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 308 6x29 G.H5 Y 354 G.H5.26
Polar TM5 Q 242 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 Q 242 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 Q 242 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 155 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 V 155 34x51 G.s2s3 K 192 G.s2s3.01
Polar TM6 T 315 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 315 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 315 6x36 G.H5 G 352 G.H5.24
Polar TM5 Q 242 5x72 G.H5 Y 354 G.H5.26
Van-der-waals TM5 Q 242 5x72 G.H5 Y 354 G.H5.26
Polar TM6 R 308 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 308 6x29 G.h4s6 D 315 G.h4s6.09
Ionic ICL1 R 78 12x48 G.HN D 20 G.HN.44
Polar ICL1 R 78 12x48 G.HN D 20 G.HN.44
Hydrophobic ICL2 V 155 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 V 155 34x51 G.H5 T 340 G.H5.12
Ionic ICL2 R 161 34x57 G.H5 E 350 G.H5.22
Polar ICL2 R 161 34x57 G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 161 34x57 G.H5 E 350 G.H5.22
Hydrophobic ICL2 A 154 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 154 34x50 G.H5 I 344 G.H5.16
Ionic TM5 R 238 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 238 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 238 5x68 G.H5 D 341 G.H5.13