Gq -
5-HT1E receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | I | 205 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM5 | I | 205 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | Y | 213 | 5x69 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM5 | Y | 213 | 5x69 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM5 | A | 209 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Ionic | ICL2 | R | 134 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | R | 134 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | R | 134 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | R | 285 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | I | 292 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | I | 292 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | E | 129 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | E | 129 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | E | 129 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL3 | S | 223 | - | G.H4 | V | 314 | G.H4.16 |
Ionic | TM6 | R | 285 | 6x29 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 285 | 6x29 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | L | 293 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 293 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | A | 57 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | A | 57 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Ionic | ICL3 | R | 225 | - | G.H4 | D | 315 | G.H4.17 |
Polar | ICL3 | R | 225 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | TM3 | R | 120 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 120 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | A | 123 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 123 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 123 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | R | 134 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 134 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | R | 134 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | N | 224 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | N | 224 | - | G.H4 | E | 307 | G.H4.09 |
Polar | H8 | N | 348 | 8x47 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM5 | L | 212 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | L | 212 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | I | 128 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | I | 128 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | TM5 | R | 220 | 5x76 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM5 | R | 220 | 5x76 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | TM5 | R | 216 | 5x72 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM5 | R | 216 | 5x72 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | R | 216 | 5x72 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | A | 127 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Polar | ICL3 | S | 223 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | N | 224 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM3 | A | 123 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 123 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | H8 | N | 348 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 348 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | TM5 | Y | 213 | 5x69 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM5 | Y | 213 | 5x69 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | A | 289 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 289 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | I | 292 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | A | 127 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Polar | ICL3 | L | 222 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | L | 222 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | I | 128 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Polar | ICL3 | R | 225 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 225 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Polar | TM6 | K | 288 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | K | 288 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 288 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | TM7 | F | 347 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | F | 347 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | F | 347 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | R | 216 | 5x72 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM5 | R | 216 | 5x72 | G.h4s6 | I | 323 | G.h4s6.20 |
Ionic | TM5 | R | 216 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | R | 216 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | R | 216 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | R | 216 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | R | 216 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | R | 216 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM5 | Y | 213 | 5x69 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | S | 226 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL3 | S | 226 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | S | 226 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL2 | R | 132 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | R | 132 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM5 | L | 212 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | L | 212 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Polar | TM3 | D | 119 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | L | 212 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | L | 212 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | L | 212 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | L | 212 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | R | 225 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | ICL3 | R | 225 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | R | 225 | - | G.H4 | V | 314 | G.H4.16 |