G12 - 5-HT4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 122 3x54 G.H5 L 375 G.H5.20
Polar ICL2 N 131 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 131 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 131 34x55 G.hns1 R 56 G.hns1.03
Polar ICL3 S 235 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 S 235 - G.H4 R 329 G.H4.09
Hydrophobic TM5 I 226 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 226 5x72 G.H5 Q 372 G.H5.17
Van-der-waals ICL2 P 126 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM5 H 222 5x68 G.H5 L 375 G.H5.20
Hydrophobic C-term V 362 - G.H3 L 285 G.H3.17
Hydrophobic TM7 L 315 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 315 7x56 G.H5 L 380 G.H5.25
Hydrophobic C-term V 362 - G.H3 N 283 G.H3.15
Van-der-waals C-term V 362 - G.H3 N 283 G.H3.15
Hydrophobic C-term V 362 - G.h2s4 F 242 G.h2s4.01
Polar TM3 R 118 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 118 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 118 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term T 355 - G.H3 N 275 G.H3.07
Hydrophobic ICL2 L 127 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 I 226 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 127 34x51 G.H5 V 366 G.H5.11
Hydrophobic H8 K 317 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM2 K 54 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 K 54 2x38 G.hns1 R 55 G.hns1.02
Hydrophobic C-term A 361 - G.H2 F 239 G.H2.08
Hydrophobic TM3 R 118 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 118 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 121 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 121 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 122 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 122 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 S 236 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 S 236 - G.H4 R 329 G.H4.09
Hydrophobic TM6 I 264 6x40 G.H5 L 380 G.H5.25
Polar H8 N 316 8x47 G.H5 D 377 G.H5.22
Hydrophobic H8 N 316 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 316 8x47 G.H5 L 380 G.H5.25
Hydrophobic C-term L 358 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM5 G 233 5x79 G.S6 H 348 G.S6.03
Hydrophobic ICL2 R 130 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 A 219 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 219 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 A 219 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 256 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 256 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 122 3x54 G.H5 N 374 G.H5.19
Hydrophobic C-term R 359 - G.H3 T 279 G.H3.11
Hydrophobic TM5 H 222 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 222 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 126 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 127 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 I 221 G.S3.01
Polar C-term S 354 - G.H2 R 232 G.H2.01
Hydrophobic C-term S 354 - G.H2 R 232 G.H2.01
Van-der-waals C-term S 354 - G.H2 R 232 G.H2.01
Hydrophobic TM5 T 218 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 229 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 229 5x75 G.S6 F 347 G.S6.02
Polar TM7 L 315 7x56 G.H5 Q 381 G.H5.26
Polar ICL2 R 130 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 130 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 130 34x54 G.hns1 R 55 G.hns1.02
Polar ICL3 S 236 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 S 236 - G.H4 Q 333 G.H4.13
Ionic TM5 H 222 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 222 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic C-term L 358 - G.H3 I 280 G.H3.12
Polar TM3 A 121 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 121 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 121 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 128 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 128 34x52 G.S3 I 221 G.S3.01
Hydrophobic C-term L 358 - G.H2 W 238 G.H2.07
Van-der-waals C-term L 358 - G.H2 W 238 G.H2.07
Hydrophobic C-term L 358 - G.H3 I 276 G.H3.08
Hydrophobic ICL2 P 126 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 T 260 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 127 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 H 222 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 222 5x68 G.H5 L 371 G.H5.16
Hydrophobic C-term L 358 - G.H2 R 235 G.H2.04
Ionic ICL3 E 237 - G.hgh4 R 318 G.hgh4.06
Polar ICL1 K 52 12x52 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 52 12x52 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 Q 230 5x76 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 358 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 L 127 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM4 P 135 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 I 122 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 122 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 257 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 257 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term V 357 - G.H2 Q 236 G.H2.05
Van-der-waals C-term V 357 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 L 127 34x51 G.H5 K 367 G.H5.12