Go - 5-HT5A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 143 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 146 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 H 146 34x50 G.H5 I 344 G.H5.16
Polar TM5 R 234 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 234 5x72 G.S6 Y 320 G.S6.02
Polar H8 K 343 8x48 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 K 343 8x48 G.h4s6 N 316 G.h4s6.10
Hydrophobic TM5 R 230 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 230 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM4 K 155 4x39 G.HN I 28 G.HN.52
Polar TM6 W 275 6x25 G.h4s6 P 315 G.h4s6.09
Hydrophobic TM5 V 231 5x69 G.H5 Y 354 G.H5.26
Van-der-waals TM5 V 231 5x69 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 M 147 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 M 147 34x51 G.s2s3 K 193 G.s2s3.01
Ionic TM6 K 279 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 279 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 279 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM4 L 151 4x35 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 L 151 4x35 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 M 147 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 147 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 T 150 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 150 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM4 R 152 4x36 G.HN I 28 G.HN.52
Van-der-waals TM4 R 152 4x36 G.HN I 28 G.HN.52
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 230 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 230 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 M 147 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 I 242 - G.H4 A 306 G.H4.13
Van-der-waals ICL3 I 242 - G.H4 A 306 G.H4.13
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 353 G.H5.25
Polar TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 279 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 M 286 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 286 6x36 G.H5 G 352 G.H5.24
Ionic TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 234 5x72 G.h4s6 E 318 G.h4s6.12
Ionic ICL1 R 69 12x48 G.HN E 20 G.HN.44
Polar ICL1 R 69 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL1 R 69 12x48 G.HN E 20 G.HN.44
Van-der-waals ICL1 R 69 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL2 M 147 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 M 147 34x51 G.H5 F 336 G.H5.08
Polar ICL1 H 72 12x51 G.HN K 24 G.HN.48
Van-der-waals ICL1 H 72 12x51 G.HN K 24 G.HN.48
Hydrophobic ICL3 P 241 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 P 241 - G.H4 E 309 G.H4.16
Ionic TM5 R 234 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 234 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 234 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 A 227 5x65 G.H5 L 348 G.H5.20
Polar H8 N 342 8x47 G.H5 G 350 G.H5.22
Hydrophobic ICL2 H 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 143 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 S 238 5x76 G.S6 I 319 G.S6.01
Van-der-waals TM5 S 238 5x76 G.S6 I 319 G.S6.01
Hydrophobic TM5 S 238 5x76 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 V 239 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 V 239 - G.H4 Q 305 G.H4.12
Polar TM5 N 237 5x75 G.S6 C 321 G.S6.03
Van-der-waals TM5 N 237 5x75 G.S6 C 321 G.S6.03
Hydrophobic TM6 M 286 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 286 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 282 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 282 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 282 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 I 344 G.H5.16
Polar ICL3 V 239 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 V 239 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 V 239 - G.H4 E 309 G.H4.16
Polar TM6 A 283 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 283 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 283 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 287 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 287 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 N 237 5x75 G.S6 Y 320 G.S6.02
Van-der-waals TM5 N 237 5x75 G.S6 Y 320 G.S6.02
Hydrophobic TM4 L 151 4x35 G.HN I 28 G.HN.52
Hydrophobic ICL3 P 241 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 P 241 - G.h4s6 N 312 G.h4s6.02
Hydrophobic TM5 R 230 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 223 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 146 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 146 34x50 G.H5 T 340 G.H5.12
Polar TM3 S 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 347 G.H5.19
Polar TM5 R 234 5x72 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 234 5x72 G.H5 Y 354 G.H5.26
Van-der-waals TM5 R 234 5x72 G.H5 Y 354 G.H5.26