G12 - 5-HT7 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 280 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 R 280 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 R 280 - G.H4 Q 333 G.H4.13
Hydrophobic TM3 I 184 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 184 3x54 G.H5 L 371 G.H5.16
Aromatic TM5 F 275 5x74 G.S6 H 348 G.S6.03
Hydrophobic TM5 F 275 5x74 G.S6 H 348 G.S6.03
Van-der-waals TM5 F 275 5x74 G.S6 H 348 G.S6.03
Hydrophobic TM5 F 275 5x74 G.S6 F 347 G.S6.02
Hydrophobic ICL2 T 189 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 189 34x52 G.S3 I 221 G.S3.01
Polar H8 C 401 8x60 G.HN T 7 G.HN.07
Hydrophobic H8 C 401 8x60 G.HN T 7 G.HN.07
Hydrophobic C-term L 421 - G.H3 K 284 G.H3.16
Van-der-waals C-term L 421 - G.H3 K 284 G.H3.16
Hydrophobic TM5 S 269 5x68 G.H5 L 375 G.H5.20
Hydrophobic C-term L 421 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 421 - G.H3 L 285 G.H3.17
Hydrophobic TM6 I 331 6x39 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 331 6x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 188 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 F 278 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 F 278 - G.H4 R 329 G.H4.09
Polar ICL2 V 192 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 192 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 192 34x55 G.hns1 R 56 G.hns1.03
Polar H8 R 392 8x51 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 392 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 392 8x51 G.H5 Q 381 G.H5.26
Hydrophobic TM7 F 387 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 387 7x56 G.H5 L 380 G.H5.25
Polar TM2 Q 114 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 Q 114 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 Q 114 2x37 G.hns1 R 55 G.hns1.02
Ionic ICL1 K 110 12x48 G.HN D 44 G.HN.44
Polar ICL1 K 110 12x48 G.HN D 44 G.HN.44
Hydrophobic ICL1 K 110 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 K 110 12x48 G.HN D 44 G.HN.44
Polar TM3 G 183 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 183 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 H 273 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term A 418 - G.H3 L 285 G.H3.17
Van-der-waals C-term A 418 - G.H3 L 285 G.H3.17
Polar TM6 T 328 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 328 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 328 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 180 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 180 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 187 34x50 G.H5 I 370 G.H5.15
Polar H8 C 401 8x60 G.HN C 11 G.HN.11
Hydrophobic H8 C 401 8x60 G.HN C 11 G.HN.11
Van-der-waals H8 C 401 8x60 G.HN C 11 G.HN.11
Polar TM6 R 321 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 321 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 A 325 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 325 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 188 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 188 34x51 G.H5 F 363 G.H5.08
Polar TM3 T 185 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 T 185 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 188 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 F 275 5x74 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 F 275 5x74 G.S6 L 346 G.S6.01
Van-der-waals TM5 F 275 5x74 G.S6 L 346 G.S6.01
Hydrophobic TM6 T 328 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 328 6x36 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 188 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 188 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM7 F 386 7x55 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 386 7x55 G.H5 L 380 G.H5.25
Hydrophobic ICL3 F 278 - G.H4 V 332 G.H4.12
Hydrophobic TM3 I 184 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 184 3x54 G.H5 I 378 G.H5.23
Ionic TM5 H 273 5x72 G.H5 D 368 G.H5.13
Polar TM5 H 273 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 273 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 273 5x72 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 188 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 188 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 A 266 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 266 5x65 G.H5 L 375 G.H5.20
Polar H8 R 389 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 389 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 389 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 184 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 184 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 K 324 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 324 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 324 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 324 6x32 G.H5 Q 381 G.H5.26
Ionic TM5 K 272 5x71 G.H5 D 368 G.H5.13
Polar TM5 K 272 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 272 5x71 G.H5 D 368 G.H5.13
Polar TM6 K 324 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 324 6x32 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 324 6x32 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 187 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 187 34x50 G.H5 K 367 G.H5.12
Hydrophobic C-term L 421 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 421 - G.H3 N 283 G.H3.15
Aromatic TM5 H 273 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM5 H 273 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 H 273 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM4 N 195 4x38 G.HN R 52 G.HN.52
Polar TM6 R 321 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 321 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 321 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM5 S 269 5x68 G.H5 L 371 G.H5.16
Polar TM5 S 269 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 269 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 I 184 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 188 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 188 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 T 328 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 328 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM1 L 90 1x41 G.HN M 1 G.HN.01
Van-der-waals TM1 L 90 1x41 G.HN M 1 G.HN.01
Hydrophobic H8 Y 403 8x62 G.HN C 11 G.HN.11
Polar TM5 H 273 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 273 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 273 5x72 G.H5 Q 372 G.H5.17