G12 - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 142 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 142 3x50 G.H5 I 378 G.H5.23
Polar ICL2 L 155 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 155 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 155 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ECL2 F 199 - G.HN T 7 G.HN.07
Polar TM7 E 298 7x38 G.HN M 1 G.HN.01
Hydrophobic TM7 E 298 7x38 G.HN M 1 G.HN.01
Van-der-waals TM7 E 298 7x38 G.HN M 1 G.HN.01
Polar ICL3 R 241 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 R 241 - G.H5 Q 372 G.H5.17
Hydrophobic TM5 T 204 5x33 G.HN T 7 G.HN.07
Van-der-waals TM5 T 204 5x33 G.HN T 7 G.HN.07
Hydrophobic TM5 L 237 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 237 5x65 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 151 34x52 G.S1 L 57 G.S1.01
Ionic ICL2 H 153 34x54 G.h2s4 D 243 G.h2s4.02
Polar ICL2 H 153 34x54 G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL2 H 153 34x54 G.h2s4 D 243 G.h2s4.02
Van-der-waals ICL2 H 153 34x54 G.h2s4 D 243 G.h2s4.02
Hydrophobic TM5 L 240 5x68 G.S3 I 221 G.S3.01
Hydrophobic TM1 K 38 1x24 G.HN V 4 G.HN.04
Polar ICL2 Y 152 34x53 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 Y 152 34x53 G.H5 Q 381 G.H5.26
Van-der-waals ICL2 Y 152 34x53 G.H5 Q 381 G.H5.26
Polar C-term I 352 - G.H2 Q 236 G.H2.05
Van-der-waals C-term I 352 - G.H2 Q 236 G.H2.05
Hydrophobic TM1 Y 53 1x39 G.HN M 1 G.HN.01
Hydrophobic TM7 F 302 7x42 G.HN M 1 G.HN.01
Van-der-waals TM7 F 302 7x42 G.HN M 1 G.HN.01
Hydrophobic TM5 L 237 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term M 362 - H.HA K 114 H.HA.28
Van-der-waals C-term M 362 - H.HA K 114 H.HA.28
Hydrophobic TM3 I 146 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 375 G.H5.20
Polar TM6 A 243 6x28 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 243 6x28 G.H5 Q 372 G.H5.17
Van-der-waals TM6 A 243 6x28 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 240 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 240 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM2 W 102 2x60 G.HN M 1 G.HN.01
Van-der-waals TM2 W 102 2x60 G.HN M 1 G.HN.01
Hydrophobic N-term L 35 - G.HN R 6 G.HN.06
Van-der-waals N-term L 35 - G.HN R 6 G.HN.06
Hydrophobic ICL3 P 242 - G.H5 L 375 G.H5.20
Polar TM5 T 204 5x33 G.HN L 8 G.HN.08
Hydrophobic TM5 T 204 5x33 G.HN L 8 G.HN.08
Van-der-waals TM5 T 204 5x33 G.HN L 8 G.HN.08
Polar C-term S 343 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 343 - G.H3 K 284 G.H3.16
Hydrophobic TM3 I 146 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 146 3x54 G.H5 M 379 G.H5.24
Polar TM6 D 277 6x62 G.HN T 7 G.HN.07
Hydrophobic TM6 D 277 6x62 G.HN T 7 G.HN.07
Van-der-waals TM6 D 277 6x62 G.HN T 7 G.HN.07
Hydrophobic TM6 A 248 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 248 6x33 G.H5 M 379 G.H5.24
Polar C-term A 342 - G.H3 K 284 G.H3.16
Hydrophobic C-term A 342 - G.H3 K 284 G.H3.16
Van-der-waals C-term A 342 - G.H3 K 284 G.H3.16
Hydrophobic TM6 L 278 6x63 G.HN S 9 G.HN.09
Hydrophobic ECL2 H 196 45x51 G.HN V 5 G.HN.05
Polar H8 S 316 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 316 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 316 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 205 5x34 G.HN L 12 G.HN.12
Hydrophobic H8 R 318 8x49 G.H5 Q 381 G.H5.26
Polar ICL2 A 149 34x50 G.S1 L 57 G.S1.01
Hydrophobic TM3 I 146 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 I 378 G.H5.23
Polar TM6 Q 279 6x64 G.HN S 9 G.HN.09
Hydrophobic TM6 Q 279 6x64 G.HN S 9 G.HN.09
Van-der-waals TM6 Q 279 6x64 G.HN S 9 G.HN.09
Hydrophobic C-term M 359 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term M 359 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM7 D 291 7x31 G.HN V 4 G.HN.04
Van-der-waals TM7 D 291 7x31 G.HN V 4 G.HN.04
Polar TM3 V 147 3x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 147 3x55 G.hns1 R 56 G.hns1.03
Van-der-waals TM3 V 147 3x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 240 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 240 5x68 G.H5 L 371 G.H5.16
Ionic TM3 D 141 3x49 G.hns1 R 55 G.hns1.02
Polar TM3 D 141 3x49 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 V 81 2x39 G.H5 Q 381 G.H5.26
Polar ICL2 H 153 34x54 G.h2s4 G 244 G.h2s4.03
Hydrophobic ICL2 H 153 34x54 G.h2s4 G 244 G.h2s4.03
Van-der-waals ICL2 H 153 34x54 G.h2s4 G 244 G.h2s4.03
Polar TM3 Y 124 3x32 G.HN M 1 G.HN.01
Hydrophobic TM3 Y 124 3x32 G.HN M 1 G.HN.01
Van-der-waals TM3 Y 124 3x32 G.HN M 1 G.HN.01
Polar H8 S 316 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 316 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 316 8x47 G.H5 Q 381 G.H5.26
Polar H8 H 317 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 H 317 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 H 317 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 A 149 34x50 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 149 34x50 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 150 34x51 G.HN R 52 G.HN.52
Ionic TM2 R 79 2x37 G.H5 D 377 G.H5.22
Polar H8 R 318 8x49 G.H5 L 380 G.H5.25
Hydrophobic C-term L 365 - H.HA K 114 H.HA.28
Polar TM5 R 211 5x40 G.HN S 2 G.HN.02
Hydrophobic ICL2 P 151 34x52 G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 P 151 34x52 G.hns1 V 54 G.hns1.01
Polar TM5 K 207 5x36 G.HN T 7 G.HN.07
Hydrophobic TM5 K 207 5x36 G.HN T 7 G.HN.07
Van-der-waals TM5 K 207 5x36 G.HN T 7 G.HN.07
Polar TM3 K 142 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 K 142 3x50 G.H5 Q 381 G.H5.26
Polar TM2 R 79 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 R 79 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 R 79 2x37 G.H5 Q 381 G.H5.26
Polar TM3 H 148 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 H 148 3x56 G.hns1 R 56 G.hns1.03
Van-der-waals TM3 H 148 3x56 G.hns1 R 56 G.hns1.03
Polar TM3 H 148 3x56 G.HN R 52 G.HN.52
Aromatic TM3 H 148 3x56 G.HN R 52 G.HN.52
Hydrophobic TM3 H 148 3x56 G.HN R 52 G.HN.52
Van-der-waals TM3 H 148 3x56 G.HN R 52 G.HN.52
Hydrophobic TM3 H 148 3x56 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 H 148 3x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 155 34x56 G.HN R 51 G.HN.51
Van-der-waals ICL2 L 155 34x56 G.HN R 51 G.HN.51
Polar H8 R 318 8x49 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 R 318 8x49 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 318 8x49 G.h3s5 N 288 G.h3s5.02
Polar TM6 D 277 6x62 G.HN S 9 G.HN.09
Van-der-waals TM6 D 277 6x62 G.HN S 9 G.HN.09
Polar TM3 E 145 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 E 145 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 E 145 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL3 P 242 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 P 242 - G.H5 Q 372 G.H5.17
Polar TM6 A 243 6x28 G.H5 K 376 G.H5.21
Hydrophobic TM6 A 243 6x28 G.H5 K 376 G.H5.21
Van-der-waals TM6 A 243 6x28 G.H5 K 376 G.H5.21
Polar TM5 K 207 5x36 G.HN V 5 G.HN.05
Hydrophobic TM5 K 207 5x36 G.HN V 5 G.HN.05
Van-der-waals TM5 K 207 5x36 G.HN V 5 G.HN.05
Ionic H8 R 318 8x49 G.H5 D 377 G.H5.22
Polar H8 R 318 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 318 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 318 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL2 A 149 34x50 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 149 34x50 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 156 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 156 34x57 G.hns1 R 55 G.hns1.02
Polar ICL2 Q 150 34x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 150 34x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 150 34x51 G.hns1 R 55 G.hns1.02
Hydrophobic ECL2 H 196 45x51 G.HN G 3 G.HN.03
Hydrophobic ECL2 A 197 45x52 G.HN V 5 G.HN.05
Van-der-waals ECL2 A 197 45x52 G.HN V 5 G.HN.05
Polar ICL2 P 151 34x52 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 151 34x52 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 151 34x52 G.hns1 R 55 G.hns1.02
Polar ICL2 Q 150 34x51 G.HN R 51 G.HN.51
Van-der-waals ICL2 Q 150 34x51 G.HN R 51 G.HN.51