G14 - ACKR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 142 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 L 354 G.H5.25
Polar H8 N 319 8x47 G.H5 L 354 G.H5.25
Polar ICL2 T 150 - G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 T 150 - G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 T 150 - G.hns1 R 34 G.hns1.03
Polar TM3 R 142 3x50 G.H5 N 353 G.H5.24
Ionic ICL2 R 156 - G.HN D 31 G.HN.53
Hydrophobic TM6 I 253 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 239 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 I 239 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 235 5x61 G.H5 L 354 G.H5.25
Polar TM5 S 242 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 242 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 242 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 I 254 6x37 G.H5 L 354 G.H5.25
Polar TM3 S 145 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 146 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 349 G.H5.20
Polar TM6 S 250 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 250 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 250 6x33 G.H5 L 354 G.H5.25
Polar TM6 E 246 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 E 246 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 246 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 I 253 6x36 G.H5 V 355 G.H5.26
Ionic H8 R 320 8x48 G.h4s6 E 317 G.h4s6.12
Polar H8 R 320 8x48 G.h4s6 E 317 G.h4s6.12
Hydrophobic H8 R 320 8x48 G.h4s6 E 317 G.h4s6.12
Van-der-waals H8 R 320 8x48 G.h4s6 E 317 G.h4s6.12
Polar TM7 Y 315 7x53 G.H5 N 353 G.H5.24
Van-der-waals TM7 Y 315 7x53 G.H5 N 353 G.H5.24
Hydrophobic ICL2 P 153 - G.HN K 30 G.HN.52
Polar H8 N 319 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 N 319 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 N 319 8x47 G.H5 N 353 G.H5.24
Hydrophobic TM3 I 146 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 L 345 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 F 352 G.H5.23
Polar H8 N 319 8x47 G.H5 V 355 G.H5.26
Van-der-waals H8 N 319 8x47 G.H5 V 355 G.H5.26
Polar TM3 R 142 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 N 151 - G.S3 I 195 G.S3.01
Van-der-waals ICL2 N 151 - G.S3 I 195 G.S3.01
Hydrophobic TM6 Y 257 6x40 G.H5 L 354 G.H5.25
Van-der-waals TM6 Y 257 6x40 G.H5 L 354 G.H5.25
Polar TM6 Y 257 6x40 G.H5 N 353 G.H5.24
Van-der-waals TM6 Y 257 6x40 G.H5 N 353 G.H5.24
Polar H8 N 321 8x49 G.H5 R 350 G.H5.21
Hydrophobic H8 N 321 8x49 G.H5 R 350 G.H5.21
Van-der-waals H8 N 321 8x49 G.H5 R 350 G.H5.21
Polar TM2 H 80 2x40 G.H5 F 352 G.H5.23
Aromatic TM2 H 80 2x40 G.H5 F 352 G.H5.23
Hydrophobic TM2 H 80 2x40 G.H5 F 352 G.H5.23
Van-der-waals TM2 H 80 2x40 G.H5 F 352 G.H5.23
Hydrophobic ICL2 T 150 - G.H5 I 344 G.H5.15
Polar H8 R 320 8x48 G.H5 V 355 G.H5.26
Van-der-waals H8 R 320 8x48 G.H5 V 355 G.H5.26
Polar ICL2 N 151 - G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 N 151 - G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 N 151 - G.hns1 R 34 G.hns1.03
Polar TM2 Y 77 2x37 G.h3s5 N 262 G.h3s5.02
Hydrophobic TM3 S 145 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM3 D 141 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 D 141 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM5 S 242 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 S 242 5x68 G.H5 L 345 G.H5.16
Polar ICL2 R 156 - G.HN K 30 G.HN.52
Ionic TM2 H 80 2x40 G.H5 E 351 G.H5.22
Polar TM2 H 80 2x40 G.H5 E 351 G.H5.22
Hydrophobic TM2 H 80 2x40 G.H5 E 351 G.H5.22
Van-der-waals TM2 H 80 2x40 G.H5 E 351 G.H5.22
Hydrophobic TM4 R 161 4x42 G.H5 F 352 G.H5.23
Van-der-waals TM4 R 161 4x42 G.H5 F 352 G.H5.23
Ionic TM4 R 161 4x42 G.H5 E 351 G.H5.22
Polar TM4 R 161 4x42 G.H5 E 351 G.H5.22
Hydrophobic TM4 R 161 4x42 G.H5 E 351 G.H5.22
Van-der-waals TM4 R 161 4x42 G.H5 E 351 G.H5.22
Hydrophobic TM3 I 146 3x54 G.H5 N 348 G.H5.19