G12 - MC2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 136 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 H 203 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 132 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 132 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 207 5x72 G.S6 F 347 G.S6.02
Polar ICL2 H 139 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 139 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 139 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 207 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 207 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 132 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 132 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 H 203 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 203 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM7 R 279 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 279 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 A 135 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 135 34x50 G.H5 I 370 G.H5.15
Polar ICL1 Q 56 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL1 Q 56 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 Q 56 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 136 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 136 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 132 3x54 G.H5 N 374 G.H5.19
Polar ICL2 R 137 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 R 137 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 L 136 34x51 G.H5 V 366 G.H5.11
Polar TM3 T 131 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 T 131 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 T 131 3x53 G.H5 N 374 G.H5.19
Polar TM6 T 220 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM6 T 220 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 220 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM5 I 207 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 I 207 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 136 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 136 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 136 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 136 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 G 217 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 217 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 136 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 136 34x51 G.S3 I 221 G.S3.01
Ionic TM5 H 203 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 203 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 203 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 203 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 A 200 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 200 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 137 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 137 34x52 G.S3 I 221 G.S3.01
Polar TM3 F 133 3x55 G.H5 K 367 G.H5.12
Polar TM6 T 220 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 220 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 220 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 216 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 132 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 132 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 199 5x64 G.H5 L 371 G.H5.16
Polar TM6 T 220 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 220 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 220 6x36 G.H5 M 379 G.H5.24
Polar ICL2 H 139 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 139 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 139 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 H 203 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 128 3x50 G.H5 I 378 G.H5.23