Ggust - α1A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 17.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 270 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 270 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 128 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 128 3x54 G.H5 L 353 G.H5.25
Ionic TM6 K 263 6x26 G.H5 D 341 G.H5.13
Polar TM6 K 263 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 263 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 263 6x26 G.H5 D 341 G.H5.13
Polar ICL2 R 133 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 133 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Polar TM7 S 329 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 266 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 266 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 133 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 133 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 131 34x50 G.H5 I 344 G.H5.16
Polar TM4 R 142 4x41 G.HN Q 24 G.HN.48
Hydrophobic TM4 R 142 4x41 G.HN Q 24 G.HN.48
Van-der-waals TM4 R 142 4x41 G.HN Q 24 G.HN.48
Hydrophobic ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Aromatic ICL3 H 256 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 H 256 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 H 256 - G.H5 F 334 G.H5.06
Polar TM3 R 124 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 G 127 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 G 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 137 34x56 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 I 137 34x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 V 207 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 266 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 266 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM2 T 61 2x39 G.H5 C 351 G.H5.23
Polar ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 128 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 128 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 124 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 124 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 124 3x50 G.H5 G 352 G.H5.24
Hydrophobic H8 S 330 8x47 G.H5 G 352 G.H5.24
Ionic H8 K 335 8x52 G.h4s6 D 316 G.h4s6.10
Hydrophobic C-term F 399 - G.H2 K 209 G.H2.05
Van-der-waals C-term F 399 - G.H2 K 209 G.H2.05
Van-der-waals ICL2 L 132 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 218 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 218 5x72 G.H5 D 341 G.H5.13
Polar ICL2 L 132 34x51 G.S1 T 33 G.S1.01
Hydrophobic C-term L 459 - G.H2 H 213 G.H2.09
Hydrophobic ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Polar ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Polar C-term C 395 - G.H3 K 257 G.H3.16
Hydrophobic TM6 L 274 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 274 6x37 G.H5 L 353 G.H5.25
Polar ICL2 T 136 34x55 G.hns1 D 30 G.hns1.01
Hydrophobic ICL2 T 136 34x55 G.hns1 D 30 G.hns1.01
Van-der-waals ICL2 T 136 34x55 G.hns1 D 30 G.hns1.01
Ionic H8 E 332 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 124 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.H5 I 344 G.H5.16
Ionic H8 K 335 8x52 G.h4s6 E 315 G.h4s6.09
Polar H8 K 335 8x52 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 K 335 8x52 G.h4s6 E 315 G.h4s6.09
Polar ICL2 T 136 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 136 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 136 34x55 G.hns1 A 31 G.hns1.02
Polar TM6 K 269 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 269 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 269 6x32 G.H5 F 354 G.H5.26
Van-der-waals ICL2 L 132 34x51 G.H5 N 347 G.H5.19