G12 - α1D-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 68.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 288 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 288 5x72 G.S6 F 347 G.S6.02
Hydrophobic ICL2 S 201 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term V 542 - G.H2 Q 240 G.H2.09
Van-der-waals C-term V 542 - G.H2 Q 240 G.H2.09
Polar C-term E 569 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term E 569 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term E 569 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term I 572 - H.HA K 114 H.HA.28
Polar C-term E 569 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 569 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term E 569 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM5 V 277 5x61 G.H5 I 378 G.H5.23
Polar TM6 R 342 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 342 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 K 345 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 345 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 202 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 202 34x51 G.S3 I 221 G.S3.01
Hydrophobic C-term L 544 - G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL2 L 202 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 V 280 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 202 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 202 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 V 292 - G.h4s6 P 345 G.h4s6.20
Polar C-term L 567 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 567 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term I 572 - H.HA L 115 H.HA.29
Van-der-waals C-term I 572 - H.HA L 115 H.HA.29
Hydrophobic TM5 T 284 5x68 G.H5 L 375 G.H5.20
Hydrophobic C-term V 546 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 L 202 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 202 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 S 201 34x50 G.H5 L 371 G.H5.16
Ionic TM4 E 210 4x39 G.hns1 R 55 G.hns1.02
Polar TM4 E 210 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 E 210 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 288 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM7 S 405 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 S 405 7x56 G.H5 L 380 G.H5.25
Polar C-term T 570 - H.HA D 110 H.HA.24
Hydrophobic C-term T 570 - H.HA D 110 H.HA.24
Van-der-waals C-term T 570 - H.HA D 110 H.HA.24
Polar ICL2 K 203 34x52 G.s2s3 K 219 G.s2s3.01
Ionic C-term E 569 - H.HA K 103 H.HA.17
Polar C-term E 569 - H.HA K 103 H.HA.17
Hydrophobic C-term E 569 - H.HA K 103 H.HA.17
Van-der-waals C-term E 569 - H.HA K 103 H.HA.17
Hydrophobic C-term T 570 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term T 570 - H.HA V 107 H.HA.21
Van-der-waals C-term T 570 - H.HA V 107 H.HA.21
Polar TM6 T 349 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 349 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 349 6x36 G.H5 M 379 G.H5.24
Polar ICL3 K 293 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 K 293 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 K 293 - G.S6 H 348 G.S6.03
Polar C-term C 533 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term C 533 - G.h1ha R 83 G.h1ha.02
Polar C-term Y 564 - G.s4h3 E 263 G.s4h3.10
Hydrophobic C-term Y 564 - G.s4h3 E 263 G.s4h3.10
Van-der-waals C-term Y 564 - G.s4h3 E 263 G.s4h3.10
Hydrophobic C-term Y 559 - G.H3 N 275 G.H3.07
Van-der-waals C-term Y 559 - G.H3 N 275 G.H3.07
Hydrophobic C-term I 572 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term I 572 - H.HD E 172 H.HD.12
Hydrophobic C-term Y 564 - G.s4h3 D 264 G.s4h3.11
Hydrophobic ICL2 K 203 34x52 G.S3 I 221 G.S3.01
Polar TM3 R 194 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 194 3x50 G.H5 D 377 G.H5.22
Van-der-waals TM3 R 194 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM6 T 349 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 349 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 288 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 288 5x72 G.H5 Q 372 G.H5.17
Polar ICL1 Q 128 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 Q 128 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic C-term T 570 - H.HA A 111 H.HA.25
Polar C-term D 563 - G.H2 S 233 G.H2.02
Hydrophobic C-term D 563 - G.H2 S 233 G.H2.02
Van-der-waals C-term D 563 - G.H2 S 233 G.H2.02
Ionic N-term E 12 - G.HN R 30 G.HN.30
Polar N-term E 12 - G.HN R 30 G.HN.30
Van-der-waals N-term E 12 - G.HN R 30 G.HN.30
Hydrophobic C-term C 556 - G.H3 T 279 G.H3.11
Van-der-waals C-term C 556 - G.H3 T 279 G.H3.11
Hydrophobic TM4 T 209 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 209 4x38 G.hns1 R 56 G.hns1.03
Polar TM5 S 287 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 287 5x71 G.H5 D 368 G.H5.13
Polar TM3 R 194 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 194 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 194 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 E 295 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 E 295 - G.H4 R 329 G.H4.09
Polar ICL3 K 293 - G.S6 F 350 G.S6.05
Van-der-waals ICL3 K 293 - G.S6 F 350 G.S6.05
Ionic TM4 E 210 4x39 G.HN R 52 G.HN.52
Polar TM4 E 210 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 E 210 4x39 G.HN R 52 G.HN.52
Hydrophobic TM6 T 349 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 349 6x36 G.H5 I 378 G.H5.23
Hydrophobic C-term D 563 - G.s4h3 E 263 G.s4h3.10
Van-der-waals C-term D 563 - G.s4h3 E 263 G.s4h3.10
Hydrophobic C-term L 561 - G.H2 R 232 G.H2.01
Van-der-waals C-term L 561 - G.H2 R 232 G.H2.01
Polar C-term T 570 - H.HA K 114 H.HA.28
Hydrophobic C-term T 570 - H.HA K 114 H.HA.28
Van-der-waals C-term T 570 - H.HA K 114 H.HA.28
Hydrophobic C-term D 563 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term E 569 - H.HA V 107 H.HA.21
Van-der-waals C-term E 569 - H.HA V 107 H.HA.21
Polar ICL2 A 206 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 206 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 206 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term E 569 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term E 569 - G.s4h3 M 262 G.s4h3.09
Polar H8 R 407 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 407 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 407 8x48 G.H5 Q 381 G.H5.26
Ionic C-term R 536 - H.HA E 92 H.HA.06
Polar C-term R 536 - H.HA E 92 H.HA.06
Hydrophobic C-term R 536 - H.HA E 92 H.HA.06
Van-der-waals C-term R 536 - H.HA E 92 H.HA.06
Polar C-term D 563 - G.H2 R 232 G.H2.01
Van-der-waals C-term D 563 - G.H2 R 232 G.H2.01
Hydrophobic TM3 V 198 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 198 3x54 G.H5 I 378 G.H5.23
Polar TM3 G 197 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 197 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 197 3x53 G.H5 N 374 G.H5.19
Polar C-term V 550 - G.H3 K 284 G.H3.16
Hydrophobic C-term V 550 - G.H3 K 284 G.H3.16
Van-der-waals C-term V 550 - G.H3 K 284 G.H3.16
Hydrophobic ICL3 V 292 - G.S6 H 348 G.S6.03
Ionic C-term D 571 - H.HA K 114 H.HA.28
Polar C-term D 571 - H.HA K 114 H.HA.28
Hydrophobic TM5 A 281 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 198 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 198 3x54 G.H5 L 371 G.H5.16
Polar TM7 S 405 7x56 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 202 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 202 34x51 G.S1 V 58 G.S1.02
Hydrophobic C-term S 543 - G.H2 Q 240 G.H2.09
Polar C-term R 568 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term R 568 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term R 568 - G.s4h3 R 265 G.s4h3.12
Polar ICL3 K 293 - G.S6 H 349 G.S6.04
Aromatic ICL3 K 293 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 K 293 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 K 293 - G.S6 H 349 G.S6.04
Hydrophobic C-term Y 559 - G.H3 E 272 G.H3.04
Hydrophobic C-term L 567 - G.s4h3 D 264 G.s4h3.11
Hydrophobic ICL2 L 202 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 202 34x51 G.H5 I 370 G.H5.15
Polar C-term D 571 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term D 571 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 567 - G.s4h3 E 263 G.s4h3.10
Polar C-term A 541 - G.H2 Q 240 G.H2.09
Hydrophobic C-term A 541 - G.H2 Q 240 G.H2.09
Van-der-waals C-term A 541 - G.H2 Q 240 G.H2.09
Hydrophobic ICL2 P 205 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 205 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 L 350 6x37 G.H5 I 378 G.H5.23
Hydrophobic C-term L 544 - G.H2 Q 240 G.H2.09
Van-der-waals C-term L 544 - G.H2 Q 240 G.H2.09
Hydrophobic TM5 T 284 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 T 284 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 198 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 198 3x54 G.H5 L 375 G.H5.20
Polar ICL2 P 205 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 205 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 205 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 A 346 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 346 6x33 G.H5 M 379 G.H5.24
Polar ICL2 S 201 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 S 201 34x50 G.H5 K 367 G.H5.12