Arrestin-C - β3-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2024-10-31

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
β3 72.1
Arrestin-C 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM5 E 241 5x75 S6 K 73 N.S6.03
Polar TM5 E 241 5x75 S6 K 73 N.S6.03
Hydrophobic TM5 E 241 5x75 S6 K 73 N.S6.03
Van-der-waals TM5 E 241 5x75 S6 K 73 N.S6.03
Polar ICL2 L 143 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 143 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 143 34x51 S16 D 244 C.S16.01
Polar ICL2 P 142 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 142 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 142 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 E 241 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 E 241 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM3 R 135 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 135 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 143 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 143 34x51 S15 V 238 C.S15.14
Polar TM6 T 293 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 293 6x36 s5s6 I 67 N.s5s6.08
Polar TM5 Q 234 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Q 234 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 Q 234 5x68 s15s16 Y 241 C.s15s16.03
Polar ICL2 L 143 34x51 s5s6 R 61 N.s5s6.02
Aromatic ICL3 R 277 - S6 Y 76 N.S6.06
Hydrophobic ICL3 R 277 - S6 Y 76 N.S6.06
Van-der-waals ICL3 R 277 - S6 Y 76 N.S6.06
Ionic TM3 R 135 3x50 s5s6 D 63 N.s5s6.04
Polar TM3 R 135 3x50 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 R 135 3x50 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 R 135 3x50 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 G 146 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic H8 S 349 8x47 s5s6 E 65 N.s5s6.06
Polar ICL2 Y 145 34x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 A 290 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 R 144 34x52 s15s16 L 243 C.s15s16.05
Polar ICL2 R 144 34x52 s15s16 S 242 C.s15s16.04
Polar TM2 T 72 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 72 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 72 2x39 s5s6 D 63 N.s5s6.04
Polar TM3 A 138 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 A 138 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 R 278 - S5 M 52 N.S5.05
Van-der-waals ICL3 R 278 - S5 M 52 N.S5.05
Polar ICL3 G 276 - S6 T 79 N.S6.09
Hydrophobic ICL3 G 276 - S6 T 79 N.S6.09
Van-der-waals ICL3 G 276 - S6 T 79 N.S6.09
Hydrophobic ICL3 R 277 - S6 Q 78 N.S6.08
Hydrophobic TM2 M 71 2x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM2 M 71 2x38 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 L 143 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 143 34x51 S5 Y 59 N.S5.12
Polar ICL3 R 277 - S6 V 77 N.S6.07
Hydrophobic ICL3 R 277 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 277 - S6 V 77 N.S6.07
Hydrophobic ICL2 Y 145 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 145 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 L 238 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 L 238 5x72 S6 K 73 N.S6.03
Polar ICL2 A 147 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL1 R 67 12x49 s8s9 K 135 N.s8s9.09
Van-der-waals ICL1 R 67 12x49 s8s9 K 135 N.s8s9.09
Polar ICL2 L 143 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 143 34x51 S16 Y 246 C.S16.03
Polar TM3 N 141 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 N 141 3x56 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 N 141 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 V 139 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 139 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 P 142 34x50 S6 F 71 N.S6.01
Hydrophobic TM3 V 139 3x54 S6 F 71 N.S6.01
Hydrophobic ICL3 R 278 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 278 - S6 V 77 N.S6.07
Hydrophobic ICL3 F 245 - S6 Y 76 N.S6.06
Hydrophobic ICL2 L 143 34x51 s15s16 L 243 C.s15s16.05
Polar H8 P 350 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 P 350 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 P 350 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 L 294 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 142 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 142 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 F 245 - s7s8 V 117 N.s7s8.03
Hydrophobic ICL2 L 143 34x51 S9 C 137 N.S9.01
Polar ICL2 P 142 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 142 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 142 34x50 S5 Y 59 N.S5.12
Polar TM6 R 286 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 286 6x29 S6 R 72 N.S6.02
Polar ICL2 L 143 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 143 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 143 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM7 Y 346 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 346 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 P 279 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 P 279 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 G 146 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 G 146 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 R 135 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 135 3x50 s5s6 L 64 N.s5s6.05
Ionic ICL1 R 67 12x49 s5s6 D 62 N.s5s6.03
Polar ICL1 R 67 12x49 s5s6 D 62 N.s5s6.03
Polar ICL2 P 142 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 142 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 142 34x50 s15s16 S 242 C.s15s16.04
Polar ICL3 C 275 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 C 275 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 C 275 - s6h1 E 86 N.s6h1.03
Ionic ICL2 R 144 34x52 S16 D 244 C.S16.01
Polar ICL2 R 144 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 144 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 144 34x52 S16 D 244 C.S16.01
Hydrophobic TM3 A 138 3x53 s5s6 L 64 N.s5s6.05