Go - ADGRB1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 61.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 1045 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 1045 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 1044 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 L 1044 - G.H5 C 351 G.H5.23
Polar TM6 R 1131 6x34 G.H5 Y 354 G.H5.26
Aromatic TM6 R 1131 6x34 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 1131 6x34 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 1131 6x34 G.H5 Y 354 G.H5.26
Hydrophobic C-term S 1468 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term S 1468 - G.h1ha E 58 G.h1ha.01
Hydrophobic C-term C 1233 - G.H3 F 259 G.H3.17
Van-der-waals C-term C 1233 - G.H3 F 259 G.H3.17
Hydrophobic C-term M 1222 - G.H3 K 258 G.H3.16
Van-der-waals C-term M 1222 - G.H3 K 258 G.H3.16
Hydrophobic TM5 I 1123 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 1123 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM4 R 1052 4x45 G.HN K 24 G.HN.48
Polar C-term E 1226 - G.H3 S 253 G.H3.11
Hydrophobic C-term L 1348 - H.HA V 72 H.HA.10
Van-der-waals C-term L 1348 - H.HA V 72 H.HA.10
Hydrophobic TM5 T 1124 5x68 G.H5 D 337 G.H5.09
Hydrophobic C-term T 1343 - H.HA R 86 H.HA.24
Van-der-waals C-term T 1343 - H.HA R 86 H.HA.24
Polar C-term E 1483 - G.H2 H 214 G.H2.09
Hydrophobic C-term E 1483 - G.H2 H 214 G.H2.09
Van-der-waals C-term E 1483 - G.H2 H 214 G.H2.09
Hydrophobic C-term F 1482 - G.H2 C 215 G.H2.10
Van-der-waals C-term F 1482 - G.H2 C 215 G.H2.10
Polar C-term S 1468 - G.S2 T 191 G.S2.07
Hydrophobic C-term S 1468 - G.S2 T 191 G.S2.07
Van-der-waals C-term S 1468 - G.S2 T 191 G.S2.07
Hydrophobic C-term L 1348 - H.HA Q 68 H.HA.06
Polar ICL3 D 1125 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 D 1125 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 D 1125 - G.H5 D 341 G.H5.13
Hydrophobic C-term R 1472 - G.H1 V 50 G.H1.05
Hydrophobic C-term Y 1477 - G.S3 F 200 G.S3.06
Hydrophobic ICL3 L 1128 - G.H5 L 348 G.H5.20
Hydrophobic C-term L 1470 - G.H1 K 54 G.H1.09
Van-der-waals C-term L 1470 - G.H1 K 54 G.H1.09
Hydrophobic C-term L 1470 - G.S2 T 188 G.S2.04
Van-der-waals C-term L 1470 - G.S2 T 188 G.S2.04
Polar C-term T 1343 - G.s4h3 H 236 G.s4h3.09
Polar C-term S 1469 - G.h1ha E 58 G.h1ha.01
Hydrophobic C-term S 1469 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term S 1469 - G.h1ha E 58 G.h1ha.01
Hydrophobic H8 E 1190 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 E 1190 8x49 G.H5 G 352 G.H5.24
Ionic C-term D 1228 - G.H2 K 210 G.H2.05
Polar C-term D 1228 - G.H2 K 210 G.H2.05
Hydrophobic C-term D 1228 - G.H2 K 210 G.H2.05
Van-der-waals C-term D 1228 - G.H2 K 210 G.H2.05
Polar TM5 T 1124 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 T 1124 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 1124 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 1132 6x35 G.H5 L 348 G.H5.20
Polar C-term Y 1345 - G.hfs2 R 179 G.hfs2.02
Aromatic C-term Y 1345 - G.hfs2 R 179 G.hfs2.02
Hydrophobic C-term Y 1345 - G.hfs2 R 179 G.hfs2.02
Van-der-waals C-term Y 1345 - G.hfs2 R 179 G.hfs2.02
Hydrophobic C-term F 1225 - G.H2 W 212 G.H2.07
Van-der-waals C-term F 1225 - G.H2 W 212 G.H2.07
Hydrophobic C-term F 1225 - G.H3 S 253 G.H3.11
Van-der-waals C-term F 1225 - G.H3 S 253 G.H3.11
Hydrophobic C-term L 1470 - G.H1 H 57 G.H1.12
Ionic TM5 D 1121 5x65 G.s2s3 K 193 G.s2s3.01
Polar TM5 D 1121 5x65 G.s2s3 K 193 G.s2s3.01
Van-der-waals TM5 D 1121 5x65 G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term R 1472 - G.S2 V 186 G.S2.02
Van-der-waals C-term R 1472 - G.S2 V 186 G.S2.02
Hydrophobic C-term V 1229 - G.H3 F 259 G.H3.17
Hydrophobic TM3 V 1040 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 1040 3x58 G.H5 I 344 G.H5.16
Hydrophobic C-term R 1472 - G.S2 E 187 G.S2.03
Van-der-waals C-term R 1472 - G.S2 E 187 G.S2.03
Hydrophobic TM3 A 1039 3x57 G.H5 L 348 G.H5.20
Polar C-term T 1223 - G.H3 S 253 G.H3.11
Van-der-waals C-term T 1223 - G.H3 S 253 G.H3.11
Hydrophobic C-term Y 1477 - G.S2 I 185 G.S2.01
Hydrophobic C-term L 1470 - G.S2 F 190 G.S2.06
Van-der-waals C-term L 1470 - G.S2 F 190 G.S2.06
Hydrophobic C-term V 1229 - G.H2 I 213 G.H2.08
Van-der-waals C-term V 1229 - G.H2 I 213 G.H2.08
Polar TM3 G 1042 3x60 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 1042 3x60 G.H5 N 347 G.H5.19
Hydrophobic C-term V 1467 - G.h1ha D 59 G.h1ha.02
Van-der-waals C-term V 1467 - G.h1ha D 59 G.h1ha.02
Hydrophobic C-term M 1486 - G.H2 I 213 G.H2.08
Van-der-waals C-term M 1486 - G.H2 I 213 G.H2.08
Polar C-term E 1471 - G.S2 H 189 G.S2.05
Hydrophobic C-term S 1475 - G.S3 F 200 G.S3.06
Polar H8 R 1188 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 R 1188 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 R 1188 8x47 G.H5 G 352 G.H5.24
Polar ICL2 R 1045 - G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 R 1045 - G.hns1 A 30 G.hns1.01
Van-der-waals ICL2 R 1045 - G.hns1 A 30 G.hns1.01
Hydrophobic TM2 R 980 2x46 G.H5 L 353 G.H5.25
Van-der-waals TM2 R 980 2x46 G.H5 L 353 G.H5.25
Ionic C-term R 1489 - G.h2s4 E 217 G.h2s4.02
Polar C-term R 1489 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term R 1489 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term R 1489 - G.h2s4 E 217 G.h2s4.02
Polar C-term S 1475 - G.S2 I 185 G.S2.01
Hydrophobic C-term S 1475 - G.S2 I 185 G.S2.01
Van-der-waals C-term S 1475 - G.S2 I 185 G.S2.01
Hydrophobic TM3 A 1039 3x57 G.H5 C 351 G.H5.23
Hydrophobic C-term V 1346 - H.HA S 75 H.HA.13
Van-der-waals C-term V 1346 - H.HA S 75 H.HA.13
Hydrophobic C-term M 1486 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term V 1346 - H.hbhc D 116 H.hbhc.04
Ionic C-term R 1489 - G.h2s4 D 218 G.h2s4.03
Polar C-term R 1489 - G.h2s4 D 218 G.h2s4.03
Hydrophobic C-term R 1489 - G.h2s4 D 218 G.h2s4.03
Van-der-waals C-term R 1489 - G.h2s4 D 218 G.h2s4.03
Hydrophobic ICL2 L 1044 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 1044 - G.H5 N 347 G.H5.19
Hydrophobic C-term V 1346 - H.hbhc T 117 H.hbhc.05
Van-der-waals C-term V 1346 - H.hbhc T 117 H.hbhc.05
Hydrophobic C-term V 1236 - G.H2 H 214 G.H2.09
Polar TM2 S 978 2x44 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 978 2x44 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 978 2x44 G.H5 C 351 G.H5.23
Hydrophobic C-term V 1229 - G.H3 N 257 G.H3.15
Van-der-waals C-term V 1229 - G.H3 N 257 G.H3.15
Polar ICL2 R 1045 - G.HN G 27 G.HN.51
Hydrophobic ICL2 R 1045 - G.HN G 27 G.HN.51
Van-der-waals ICL2 R 1045 - G.HN G 27 G.HN.51
Hydrophobic C-term F 1482 - G.H2 K 211 G.H2.06
Van-der-waals C-term F 1482 - G.H2 K 211 G.H2.06
Polar C-term I 1485 - G.H2 H 214 G.H2.09
Hydrophobic C-term I 1485 - G.H2 H 214 G.H2.09
Van-der-waals C-term I 1485 - G.H2 H 214 G.H2.09
Hydrophobic ICL3 L 1128 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 L 1128 - G.H5 Y 354 G.H5.26
Hydrophobic C-term F 1225 - G.H3 I 254 G.H3.12
Hydrophobic C-term M 1486 - G.H3 F 259 G.H3.17
Van-der-waals C-term M 1486 - G.H3 F 259 G.H3.17
Polar C-term R 1473 - G.S2 E 187 G.S2.03
Van-der-waals C-term R 1473 - G.S2 E 187 G.S2.03
Hydrophobic C-term A 1478 - G.S2 I 185 G.S2.01
Hydrophobic TM6 R 1131 6x34 G.H5 L 348 G.H5.20
Hydrophobic C-term L 1348 - G.hfs2 V 180 G.hfs2.03
Polar TM2 R 980 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 980 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 980 2x46 G.H5 C 351 G.H5.23
Polar TM3 A 1039 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 1039 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 1039 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 1123 5x67 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 1123 5x67 G.H5 I 344 G.H5.16
Hydrophobic TM3 G 1042 3x60 G.H5 I 343 G.H5.15
Hydrophobic C-term F 1482 - G.S2 I 185 G.S2.01
Hydrophobic C-term M 1486 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term M 1486 - G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term V 1467 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term V 1467 - G.h1ha E 58 G.h1ha.01
Polar C-term M 1486 - G.H2 H 214 G.H2.09
Hydrophobic C-term M 1486 - G.H2 H 214 G.H2.09
Van-der-waals C-term M 1486 - G.H2 H 214 G.H2.09
Hydrophobic C-term S 1475 - G.S2 E 187 G.S2.03
Hydrophobic ICL3 L 1128 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 1128 - G.H5 I 344 G.H5.16
Ionic C-term D 1342 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term L 1470 - G.H1 M 53 G.H1.08
Polar C-term L 1470 - G.h1ha E 58 G.h1ha.01
Hydrophobic C-term L 1470 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term L 1470 - G.h1ha E 58 G.h1ha.01
Hydrophobic ICL3 L 1128 - G.H5 A 345 G.H5.17
Van-der-waals ICL3 L 1128 - G.H5 A 345 G.H5.17
Polar H8 R 1188 8x47 G.H5 C 351 G.H5.23
Hydrophobic C-term A 1232 - G.H2 I 213 G.H2.08
Van-der-waals C-term A 1232 - G.H2 I 213 G.H2.08
Ionic C-term R 1472 - G.S3 D 201 G.S3.07
Polar C-term R 1472 - G.S3 D 201 G.S3.07
Van-der-waals C-term R 1472 - G.S3 D 201 G.S3.07
Hydrophobic C-term F 1225 - G.H3 L 250 G.H3.08
Hydrophobic TM6 S 1135 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 1135 6x38 G.H5 L 353 G.H5.25
Hydrophobic C-term F 1482 - G.H2 W 212 G.H2.07
Van-der-waals C-term F 1482 - G.H2 W 212 G.H2.07
Polar TM3 Q 1035 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 1035 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Q 1035 3x53 G.H5 C 351 G.H5.23
Polar C-term L 1470 - G.S2 H 189 G.S2.05
Hydrophobic C-term L 1470 - G.S2 H 189 G.S2.05
Van-der-waals C-term L 1470 - G.S2 H 189 G.S2.05
Hydrophobic C-term F 1482 - G.H2 I 213 G.H2.08
Van-der-waals C-term F 1482 - G.H2 I 213 G.H2.08
Hydrophobic C-term K 1490 - G.H3 F 259 G.H3.17
Van-der-waals C-term K 1490 - G.H3 F 259 G.H3.17
Polar C-term F 1482 - G.H2 H 214 G.H2.09
Aromatic C-term F 1482 - G.H2 H 214 G.H2.09
Hydrophobic C-term F 1482 - G.H2 H 214 G.H2.09
Van-der-waals C-term F 1482 - G.H2 H 214 G.H2.09
Polar TM2 S 978 2x44 G.H5 G 352 G.H5.24
Hydrophobic TM2 S 978 2x44 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 1128 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 1128 - G.H5 D 341 G.H5.13