Gi1 - ADGRD2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 753 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 753 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 838 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 L 838 - G.S6 I 319 G.S6.01
Hydrophobic TM5 R 834 5x68 G.H5 F 354 G.H5.26
Van-der-waals TM5 R 834 5x68 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 861 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 861 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 753 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 753 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 M 755 - G.H5 I 343 G.H5.15
Polar TM5 R 834 5x68 G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 834 5x68 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 834 5x68 G.S6 Y 320 G.S6.02
Polar ICL2 H 756 - G.S3 H 195 G.S3.02
Aromatic ICL2 H 756 - G.S3 H 195 G.S3.02
Hydrophobic ICL2 H 756 - G.S3 H 195 G.S3.02
Van-der-waals ICL2 H 756 - G.S3 H 195 G.S3.02
Hydrophobic ICL3 M 837 - G.H5 D 337 G.H5.09
Polar TM6 K 857 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 857 6x34 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 857 6x34 G.H5 F 354 G.H5.26
Hydrophobic ICL2 M 755 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 M 755 - G.hns1 A 31 G.hns1.02
Polar ICL3 S 839 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 S 839 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 S 839 - G.H4 E 308 G.H4.16
Hydrophobic ICL2 M 755 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 755 - G.S3 L 194 G.S3.01
Hydrophobic C-term L 946 - G.H3 S 252 G.H3.11
Hydrophobic TM3 K 749 3x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 P 858 6x35 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 826 5x60 G.H5 I 344 G.H5.16
Polar TM2 R 690 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 690 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 690 2x46 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 755 - G.S1 E 33 G.S1.01
Hydrophobic TM3 L 746 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 746 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 753 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 M 755 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 755 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 757 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 757 - G.hns1 R 32 G.hns1.03
Ionic TM5 R 834 5x68 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 834 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 834 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 834 5x68 G.h4s6 E 318 G.h4s6.12
Polar TM2 R 690 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 690 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 690 2x46 G.H5 C 351 G.H5.23
Polar TM3 K 749 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 749 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 749 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 755 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 755 - G.S1 V 34 G.S1.02
Polar ICL2 H 756 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 756 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 S 830 5x64 G.H5 I 344 G.H5.16
Hydrophobic C-term F 947 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 947 - G.H2 R 208 G.H2.04
Hydrophobic TM6 L 862 6x39 G.H5 L 353 G.H5.25
Polar ICL3 M 837 - G.S6 T 321 G.S6.03
Hydrophobic TM6 K 857 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 857 6x34 G.H5 L 353 G.H5.25
Polar ICL1 K 687 - G.HN R 24 G.HN.48
Hydrophobic ICL1 K 687 - G.HN R 24 G.HN.48
Van-der-waals ICL1 K 687 - G.HN R 24 G.HN.48
Ionic TM3 K 749 3x57 G.H5 D 350 G.H5.22
Polar TM5 S 830 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 830 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 830 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 746 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 746 3x54 G.H5 C 351 G.H5.23
Polar ICL3 S 839 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 S 839 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 S 839 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 L 838 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 S 839 - G.S6 T 321 G.S6.03
Hydrophobic TM3 V 750 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 837 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 M 837 - G.S6 H 322 G.S6.04
Hydrophobic TM5 R 834 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 834 5x68 G.H5 K 345 G.H5.17
Hydrophobic ICL3 M 837 - G.S6 Y 320 G.S6.02
Polar TM2 S 688 2x44 G.HN R 24 G.HN.48
Hydrophobic TM2 S 688 2x44 G.HN R 24 G.HN.48
Hydrophobic TM5 V 823 5x57 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 837 - G.H5 A 338 G.H5.10
Polar ICL3 P 840 - G.H4 E 308 G.H4.16
Van-der-waals C-term L 944 - G.H3 S 252 G.H3.11
Ionic TM5 R 833 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 833 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 833 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 833 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 T 827 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 857 6x34 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 857 6x34 G.H5 G 352 G.H5.24